CONTEXT: Disruption of frontal-subcortical and limbic networks is hypothesized to have a key role in late-life depression (LLD) and can be examined using magnetic resonance imaging (MRI) techniques. Gray matter can be examined using T1-weighted MRI, white matter using T2-weighted MRI and diffusion tensor imaging, and functional connectivity in resting-state networks using functional MRI. Although independent MRI studies have supported gray and white matter abnormalities in frontosubcortical and limbic networks and increased functional connectivity in the default-mode network in depression, no study has concurrently examined gray matter, white matter, and functional connectivity. OBJECTIVE: To examine whether results of different MRI techniques are complementary, multimodal MRI was used to compare gray matter, white matter, and resting-state networks between LLD and control groups. DESIGN: Cross-sectional, case-control, multimodal MRI analysis. SETTING: University research department. PARTICIPANTS: Thirty-six recovered participants with LLD (mean age, 71.8 years) and 25 control participants (mean age, 71.8 years). MAIN OUTCOME MEASURES: Gray matter was examined across the whole brain using voxel-based morphometry. Subcortical gray matter structures were also automatically segmented, and volumetric and shape analyses were performed. For white matter analysis, fractional anisotropy, axial diffusivity, and radial diffusivity values were examined using tract-based spatial statistics. For resting-state network analysis, correlation coefficients were compared using independent components analysis followed by dual regression. RESULTS: White matter integrity was widely reduced in LLD, without significant group differences in gray matter volumes or functional connectivity. CONCLUSIONS: The present work strongly supports the hypothesis that white matter abnormalities in frontal-subcortical and limbic networks play a key role in LLD even in the absence of changes in resting functional connectivity and gray matter. Factors that could contribute to the lack of significant differences in gray matter and functional connectivity measures, including current symptom severity, medication status, and age of participants with LLD, are discussed.
CONTEXT: Disruption of frontal-subcortical and limbic networks is hypothesized to have a key role in late-life depression (LLD) and can be examined using magnetic resonance imaging (MRI) techniques. Gray matter can be examined using T1-weighted MRI, white matter using T2-weighted MRI and diffusion tensor imaging, and functional connectivity in resting-state networks using functional MRI. Although independent MRI studies have supported gray and white matter abnormalities in frontosubcortical and limbic networks and increased functional connectivity in the default-mode network in depression, no study has concurrently examined gray matter, white matter, and functional connectivity. OBJECTIVE: To examine whether results of different MRI techniques are complementary, multimodal MRI was used to compare gray matter, white matter, and resting-state networks between LLD and control groups. DESIGN: Cross-sectional, case-control, multimodal MRI analysis. SETTING: University research department. PARTICIPANTS: Thirty-six recovered participants with LLD (mean age, 71.8 years) and 25 control participants (mean age, 71.8 years). MAIN OUTCOME MEASURES: Gray matter was examined across the whole brain using voxel-based morphometry. Subcortical gray matter structures were also automatically segmented, and volumetric and shape analyses were performed. For white matter analysis, fractional anisotropy, axial diffusivity, and radial diffusivity values were examined using tract-based spatial statistics. For resting-state network analysis, correlation coefficients were compared using independent components analysis followed by dual regression. RESULTS: White matter integrity was widely reduced in LLD, without significant group differences in gray matter volumes or functional connectivity. CONCLUSIONS: The present work strongly supports the hypothesis that white matter abnormalities in frontal-subcortical and limbic networks play a key role in LLD even in the absence of changes in resting functional connectivity and gray matter. Factors that could contribute to the lack of significant differences in gray matter and functional connectivity measures, including current symptom severity, medication status, and age of participants with LLD, are discussed.
Authors: Wenjun Li; L Tugan Muftuler; Gang Chen; B Douglas Ward; Matthew D Budde; Jennifer L Jones; Malgorzata B Franczak; Piero G Antuono; Shi-Jiang Li; Joseph S Goveas Journal: J Neurol Sci Date: 2013-12-16 Impact factor: 3.181
Authors: Howard J Aizenstein; Alexander Khalaf; Sarah E Walker; Carmen Andreescu Journal: J Geriatr Psychiatry Neurol Date: 2013-12-30 Impact factor: 2.680
Authors: Wenjun Li; Yang Wang; B Douglas Ward; Piero G Antuono; Shi-Jiang Li; Joseph S Goveas Journal: J Psychiatr Res Date: 2016-12-12 Impact factor: 4.791
Authors: Jie Yang; Mengru Zhang; Hongshik Ahn; Qing Zhang; Tony B Jin; Ien Li; Matthew Nemesure; Nandita Joshi; Haoran Jiang; Jeffrey M Miller; Robert Todd Ogden; Eva Petkova; Matthew S Milak; Mary Elizabeth Sublette; Gregory M Sullivan; Madhukar H Trivedi; Myrna Weissman; Patrick J McGrath; Maurizio Fava; Benji T Kurian; Diego A Pizzagalli; Crystal M Cooper; Melvin McInnis; Maria A Oquendo; Joseph John Mann; Ramin V Parsey; Christine DeLorenzo Journal: Hum Brain Mapp Date: 2018-08-16 Impact factor: 5.038
Authors: Harris A Eyre; Hongyu Yang; Amber M Leaver; Kathleen Van Dyk; Prabha Siddarth; Natalie St Cyr; Katherine Narr; Linda Ercoli; Bernhard T Baune; Helen Lavretsky Journal: J Affect Disord Date: 2015-09-28 Impact factor: 4.839