W E van Spil1, I A Szilagyi2. 1. University Medical Center Utrecht, Department of Rheumatology & Clinical Immunology, P.O. Box 85500, 3508 GA, Utrecht, the Netherlands. Electronic address: w.e.vanspil@umcutrecht.nl. 2. Department of General Practice, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address: i.szilagyi@erasmusmc.nl.
Abstract
OBJECTIVE: To provide an insightful summary of studies on biochemical markers for osteoarthritis (OA). DESIGN: Two investigators systematically searched the electronic PubMed database for clinical studies into soluble biochemical markers for OA in humans that were published between 01-03-2018 and 01-03-2019. Data from selected publications were systematically extracted and tabulated and were summarized in a narrative review. RESULTS: Out of 1,279 publications, 124 fulfilled all selection criteria and were selected for data extraction. The majority were around knee OA, cross-sectional in design, relatively small, and/or focused on one or a few biochemical markers. Among the intervention studies, relatively many were on non-pharmacological interventions, used clinical outcomes and/or were rather short. Some leads that were provided by this year's studies pertained to less conventional inflammatory mediators, oxidative stress, acidosis, angiogenesis and/or autoantibody formation. CONCLUSIONS: This year's biochemical marker studies did provide potential leads for therapeutic targets or other biochemical marker applications that require robust and strategic follow-up research to be validated.
OBJECTIVE: To provide an insightful summary of studies on biochemical markers for osteoarthritis (OA). DESIGN: Two investigators systematically searched the electronic PubMed database for clinical studies into soluble biochemical markers for OA in humans that were published between 01-03-2018 and 01-03-2019. Data from selected publications were systematically extracted and tabulated and were summarized in a narrative review. RESULTS: Out of 1,279 publications, 124 fulfilled all selection criteria and were selected for data extraction. The majority were around knee OA, cross-sectional in design, relatively small, and/or focused on one or a few biochemical markers. Among the intervention studies, relatively many were on non-pharmacological interventions, used clinical outcomes and/or were rather short. Some leads that were provided by this year's studies pertained to less conventional inflammatory mediators, oxidative stress, acidosis, angiogenesis and/or autoantibody formation. CONCLUSIONS: This year's biochemical marker studies did provide potential leads for therapeutic targets or other biochemical marker applications that require robust and strategic follow-up research to be validated.
Authors: Marta Torres-Torrillas; Elena Damiá; José J Cerón; José M Carrillo; Pau Peláez; Laura Miguel; Ayla Del Romero; Mónica Rubio; Joaquín J Sopena Journal: Cartilage Date: 2021-12-03 Impact factor: 3.117
Authors: M Gaisberger; J Fuchs; M Riedl; S Edtinger; R Reischl; G Grasmann; B Hölzl; F Landauer; H Dobias; F Eckstein; M Offenbächer; M Ritter; M Winklmayr Journal: Int J Biometeorol Date: 2021-03-01 Impact factor: 3.787
Authors: Eiva Bernotiene; Edvardas Bagdonas; Gailute Kirdaite; Paulius Bernotas; Ursule Kalvaityte; Ilona Uzieliene; Christian S Thudium; Heidi Hannula; Gabriela S Lorite; Mona Dvir-Ginzberg; Ali Guermazi; Ali Mobasheri Journal: Front Med (Lausanne) Date: 2020-10-21