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Literature DB >> 31880200

P53 versus inflammation: an update.

Khadeja-Tul Kubra¹, Mohammad S Akhter¹, Mohammad A Uddin¹, Nektarios Barabutis¹.

Abstract

Etiologies of human pathophysiology have been associated with states of severe inflammation. The endothelium defender P53 supports cellular functions, by orchestrating anti-inflammatory responses. The purpose of the present article is to provide an update on the mechanisms enforcing the protective actions of P53 in human homeostasis, and to discuss current efforts on the development of new therapies against inflammatory abnormalities.

Entities: Disease Gene Species

Keywords: Barrier function; endothelium; growth hormone releasing hormone

Mesh：

Substances：

Year: 2019 PMID： 31880200 PMCID： PMC6961667 DOI： 10.1080/15384101.2019.1708575

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

24 in total

1. P53 supports endothelial barrier function via APE1/Ref1 suppression.

Authors: Mohammad A Uddin; Mohammad S Akhter; Agnieszka Siejka; John D Catravas; Nektarios Barabutis
Journal: Immunobiology Date: 2019-04-18 Impact factor: 3.144

2. DNA-PK, ATM, and ATR: PIKKing on p53.

Authors: Amanda K Ashley; Christopher J Kemp
Journal: Cell Cycle Date: 2018-04-02 Impact factor: 4.534

3. GHRH antagonists support lung endothelial barrier function.

Authors: Mohammad A Uddin; Mohammad S Akhter; Sitanshu S Singh; Khadeja-Tul Kubra; Andrew V Schally; Seetharama Jois; Nektarios Barabutis
Journal: Tissue Barriers Date: 2019-10-03

4. GHRH antagonist MZ-5-156 increases the expression of AMPK in A549 lung cancer cells.

Authors: Agnieszka Siejka; Nektarios Barabutis; Andrew V Schally
Journal: Cell Cycle Date: 2011-11-01 Impact factor: 4.534

Review 5. Growth hormone-releasing hormone: extrapituitary effects in physiology and pathology.

Authors: Nektarios Barabutis; Andrew V Schally
Journal: Cell Cycle Date: 2010-10-27 Impact factor: 4.534

Review 6. Combination therapies with HSP90 inhibitors against colorectal cancer.

Authors: Kushtrim Kryeziu; Jarle Bruun; Tormod K Guren; Anita Sveen; Ragnhild A Lothe
Journal: Biochim Biophys Acta Rev Cancer Date: 2019-01-30 Impact factor: 10.680

Review 7. P53, GHRH, inflammation and cancer.

Authors: Nektarios Barabutis; Andrew V Schally; Agnieszka Siejka
Journal: EBioMedicine Date: 2018-10-19 Impact factor: 8.143

8. Antagonists of growth hormone-releasing hormone (GHRH) inhibit the growth of human malignant pleural mesothelioma.

Authors: Tania Villanova; Iacopo Gesmundo; Valentina Audrito; Nicoletta Vitale; Francesca Silvagno; Chiara Musuraca; Luisella Righi; Roberta Libener; Chiara Riganti; Paolo Bironzo; Silvia Deaglio; Mauro Papotti; Renzhi Cai; Wei Sha; Ezio Ghigo; Andrew V Schally; Riccarda Granata
Journal: Proc Natl Acad Sci U S A Date: 2019-01-18 Impact factor: 11.205

9. The many faces of p53: something for everyone.

Authors: Arnold J Levine
Journal: J Mol Cell Biol Date: 2019-07-19 Impact factor: 6.216

10. Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau.

Authors: Sarah M Waldherr; Timothy J Strovas; Taylor A Vadset; Nicole F Liachko; Brian C Kraemer
Journal: Nat Commun Date: 2019-09-30 Impact factor: 14.919

11 in total

1. Autophagy, Unfolded Protein Response and Lung Disease.

Authors: Mohammad S Akhter; Mohammad A Uddin; Khadeja-Tul Kubra; Nektarios Barabutis
Journal: Curr Res Cell Biol Date: 2020-10-15

2. Unfolded protein response in endothelial injury.

Authors: Nektarios Barabutis
Journal: Cell Cycle Date: 2022-05-26 Impact factor: 5.173

3. A glimpse at growth hormone-releasing hormone cosmos.

Authors: Nektarios Barabutis
Journal: Clin Exp Pharmacol Physiol Date: 2020-04-25 Impact factor: 2.557

4. Effects of Heat Shock Protein 90 Inhibition In the Lungs.

Authors: Mohammad A Uddin; Khadeja-Tul Kubra; Jafrin Jobayer Sonju; Mohammad S Akhter; Jois Seetharama; Nektarios Barabutis
Journal: Med Drug Discov Date: 2020-05-17

5. P53 deficiency potentiates LPS-Induced acute lung injury in vivo.

Authors: Mohammad A Uddin; Mohammad S Akhter; Khadeja-Tul Kubra; Nektarios Barabutis
Journal: Curr Res Physiol Date: 2020-07-09

6. Elucidation of the Molecular Pathways Involved in the Protective Effects of AUY-922 in LPS-Induced Inflammation in Mouse Lungs.

Authors: Mohammad S Akhter; Mohammad A Uddin; Khadeja-Tul Kubra; Nektarios Barabutis
Journal: Pharmaceuticals (Basel) Date: 2021-05-29

7. Brefeldin A and kifunensine modulate LPS-induced lung endothelial hyperpermeability in human and bovine cells.

Authors: Khadeja-Tul Kubra; Nektarios Barabutis
Journal: Am J Physiol Cell Physiol Date: 2021-06-23 Impact factor: 5.282

8. Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone-releasing hormone.

Authors: Mohammad S Akhter; Nektarios Barabutis
Journal: J Biochem Mol Toxicol Date: 2021-08-08 Impact factor: 3.568

Review 9. P53 in the impaired lungs.

Authors: Mohammad A Uddin; Nektarios Barabutis
Journal: DNA Repair (Amst) Date: 2020-08-19

10. Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction.

Authors: Khadeja-Tul Kubra; Mohammad A Uddin; Mohammad S Akhter; Nektarios Barabutis
Journal: Curr Res Toxicol Date: 2020-09-24