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Literature DB >> 31872488

Copper-Mediated Fluorination of Aryl Trisiloxanes with Nucleophilic Fluoride.

Ruth Dorel¹, Philip Boehm¹, Daniel P Schwinger¹, John F Hartwig¹.

Abstract

A method for the nucleophilic fluorination of heptamethyl aryl trisiloxanes to form fluoroarenes is reported. The reaction proceeds in the presence of Cu(OTf)2 and KHF2 as the fluoride source under mild conditions for a broad range of heptamethyltrisiloxyarenes with high functional group tolerance. The combination of this method with the silylation of aryl C-H bonds enables the regioselective fluorination of non-activated arenes controlled by steric effects following a two-step protocol.

Entities: Chemical Disease Gene

Keywords: aryl silanes; copper; fluorination; fluoroarenes; nucleophilic fluoride

Year: 2020 PMID： 31872488 PMCID： PMC7266656 DOI： 10.1002/chem.201905040

Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236

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Copper-Mediated Fluorination of Aryl Trisiloxanes with Nucleophilic Fluoride.

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