Marta Paula Pereira Coelho1, Kiara Gonçalves Dias Diniz1, Tatiana Bering1, Lucas Dos Santos Athadeu Ferreira2, Diego Alves Vieira1, Manuela Resende Costa Castro2, Maria Isabel Toulson Davidson Correia3, Gifone Aguiar Rocha4, Rosangela Teixeira5, Frederico Duarte Garcia6, Luciana Diniz Silva7. 1. Sciences Applied to Adult Health Care Post-Graduate Programme, Faculdade de Medicina, Universidade Federal de Minas Gerais, Minas Gerais, Brazil. 2. Medical undergraduate student, Faculdade de Medicina, Universidade Federal de Minas Gerais, Minas Gerais, Brazil. 3. Department of Surgery, Faculdade de Medicina, Universidade Federal de Minas Gerais, Minas Gerais, Brazil. 4. Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Minas Gerais, Brazil. 5. Sciences Applied to Adult Health Care Post-Graduate Programme, Faculdade de Medicina, Universidade Federal de Minas Gerais, Minas Gerais, Brazil; Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Minas Gerais, Brazil. 6. Sciences Applied to Adult Health Care Post-Graduate Programme, Faculdade de Medicina, Universidade Federal de Minas Gerais, Minas Gerais, Brazil; Department of Mental Health, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil. 7. Sciences Applied to Adult Health Care Post-Graduate Programme, Faculdade de Medicina, Universidade Federal de Minas Gerais, Minas Gerais, Brazil; Department of Internal Medicine, Faculdade de Medicina, Universidade Federal de Minas Gerais, Minas Gerais, Brazil. Electronic address: lucianadiniz@medicina.ufmg.br.
Abstract
OBJECTIVE: The aim of this study was to evaluate whether low skeletal muscle mass index (SMI) and low phase angle (PhA) are associated with demographic, clinical, lifestyle, and nutritional status in patients dependent on alcohol and other substances. METHODS: We prospectively included 63 individuals dependent on alcohol and other substances and 71 age- and sex-matched healthy controls. Body composition was assessed by bioelectrical impedance analysis. Subjective global assessment was used to evaluate malnutrition. All included participants underwent a psychiatric evaluation, including the administration of the Mini-International Neuropsychiatric Interview. Univariate and multivariate analysis were performed to evaluate associations between low skeletal muscle mass index (SMI) and low phase angle (PhA) and nutritional, lifestyle, and alcohol use and cocaine/crack use variables, controlling for sex and age. RESULTS: Low SMI and low PhA were identified in 11.1% and 44.5% of the substance dependents, respectively. Low midarm muscle circumference (r = 0.58; P < 0.001), low midarm muscle area (r = 051; P < 0.001), and reduced PhA (r = 0.59; P < 0.001) were positively correlated with low SMI. Multivariate analysis showed that heavy alcohol consumption (≥80 g·d· ≥5 y-1; odds ratio [OR], 2.33; 95% confidence interval [CI], 1.12-4.84; P = 0.02) and sedentary lifestyle (OR, 4.39; 95% CI, 1.29-14.89; P = 0.02) were independently associated with reduced SMI. Low PhA was independently associated with heavy alcohol consumption (OR, 3.64; 95% CI, 1.62-8.15; P = 0.002) and cocaine or crack use (OR, 3.97; 95% CI, 1.05-15.11; P = 0.04) in multivariate analysis. CONCLUSIONS: Low SMI and low PhA are independently associated with heavy alcohol consumption. Low PhA is independently associated with cocaine or crack use.
OBJECTIVE: The aim of this study was to evaluate whether low skeletal muscle mass index (SMI) and low phase angle (PhA) are associated with demographic, clinical, lifestyle, and nutritional status in patients dependent on alcohol and other substances. METHODS: We prospectively included 63 individuals dependent on alcohol and other substances and 71 age- and sex-matched healthy controls. Body composition was assessed by bioelectrical impedance analysis. Subjective global assessment was used to evaluate malnutrition. All included participants underwent a psychiatric evaluation, including the administration of the Mini-International Neuropsychiatric Interview. Univariate and multivariate analysis were performed to evaluate associations between low skeletal muscle mass index (SMI) and low phase angle (PhA) and nutritional, lifestyle, and alcohol use and cocaine/crack use variables, controlling for sex and age. RESULTS: Low SMI and low PhA were identified in 11.1% and 44.5% of the substance dependents, respectively. Low midarm muscle circumference (r = 0.58; P < 0.001), low midarm muscle area (r = 051; P < 0.001), and reduced PhA (r = 0.59; P < 0.001) were positively correlated with low SMI. Multivariate analysis showed that heavy alcohol consumption (≥80 g·d· ≥5 y-1; odds ratio [OR], 2.33; 95% confidence interval [CI], 1.12-4.84; P = 0.02) and sedentary lifestyle (OR, 4.39; 95% CI, 1.29-14.89; P = 0.02) were independently associated with reduced SMI. Low PhA was independently associated with heavy alcohol consumption (OR, 3.64; 95% CI, 1.62-8.15; P = 0.002) and cocaine or crack use (OR, 3.97; 95% CI, 1.05-15.11; P = 0.04) in multivariate analysis. CONCLUSIONS: Low SMI and low PhA are independently associated with heavy alcohol consumption. Low PhA is independently associated with cocaine or crack use.
Authors: Gregorio Bevilacqua; Stefania D'Angelo; Cathy Linaker; Alice Paul; Ilse Bloom; Jean Zhang; Faidra Laskou; Cyrus Cooper; Kate A Ward; Karen Walker-Bone; Elaine M Dennison Journal: Front Endocrinol (Lausanne) Date: 2022-05-03 Impact factor: 6.055
Authors: Paulo Sérgio de Almeida Augusto; Raissa Lima Gonçalves Pereira; Sordaini Maria Caligiorne; Brian Sabato; Bruna Rodrigues Dias Assis; Larissa Pires do Espírito Santo; Karine Dias Dos Reis; Gisele Assis Castro Goulart; Ângelo de Fátima; Maila de Castro Lourenço das Neves; Frederico Duarte Garcia Journal: Mol Psychiatry Date: 2021-08-11 Impact factor: 15.992