Xin Jin1, Qing Yang1, Ning Cai1, Zhenhai Zhang2. 1. Department of Hospital Pharmacy, Suqian Branch Jiangsu Province Hospital, 120 Suzhilu, Suqian, 223800, PR China. 2. Jiangsu Province Academy of Traditional Chinese Medicine, 100 Shizijie, Nanjing, 210000, PR China.
Abstract
Aim: Lung cancer has a very high incidence rate, and thus, there is an urgent need for novel and effective therapies. Materials & methods: In this study, we proposed a potential treatment option by combining four natural products in liposome systems. Results: In vitro studies indicated that the combination of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 exhibited a synergistic action. When these four natural products were loaded into liposome systems, we observed an increased effect. The relative action was also observed in vivo. The cisplatin group presented obvious kidney damage, whereas both cocktail therapy and cocktail liposome therapy were safer. Conclusion: Therefore, we propose cocktail liposome systems may provide a more efficient and safer treatment for lung cancer.
Aim: Lung cancer has a very high incidence rate, and thus, there is an urgent need for novel and effective therapies. Materials & methods: In this study, we proposed a potential treatment option by combining four natural products in liposome systems. Results: In vitro studies indicated that the combination of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 exhibited a synergistic action. When these four natural products were loaded into liposome systems, we observed an increased effect. The relative action was also observed in vivo. The cisplatin group presented obvious kidney damage, whereas both cocktail therapy and cocktail liposome therapy were safer. Conclusion: Therefore, we propose cocktail liposome systems may provide a more efficient and safer treatment for lung cancer.
Authors: Hadi Zare-Zardini; Ashraf Alemi; Asghar Taheri-Kafrani; Seyed Ahmad Hosseini; Hossein Soltaninejad; Amir Ali Hamidieh; Mojtaba Haghi Karamallah; Majid Farrokhifar; Mohammad Farrokhifar Journal: Drug Des Devel Ther Date: 2020-08-13 Impact factor: 4.162