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Literature DB >> 31866300

Glutamine Skipping the Q into Mitochondria.

Abstract

Imported across the plasma membrane by SLC1A5, glutamine has emerged as a metabolic fuel that is catabolized by mitochondrial glutaminase to support tumor growth. The missing link between cytoplasmic and mitochondrial glutamine metabolism is now provided by Yoo et al., identifying the mitochondrial glutamine importer as a variant of SLC1A5.

Entities: Chemical Disease Gene Species

Keywords: alternative promoter; glutamine; hypoxia; metabolism; mitochondria; transporter

Mesh：

Substances：

Year: 2019 PMID： 31866300 PMCID： PMC7758675 DOI： 10.1016/j.molmed.2019.11.004

Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951

10 in total

1. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.

Authors: Daniel K Bricker; Eric B Taylor; John C Schell; Thomas Orsak; Audrey Boutron; Yu-Chan Chen; James E Cox; Caleb M Cardon; Jonathan G Van Vranken; Noah Dephoure; Claire Redin; Sihem Boudina; Steven P Gygi; Michèle Brivet; Carl S Thummel; Jared Rutter
Journal: Science Date: 2012-05-24 Impact factor: 47.728

Review 2. The mitochondrial transporter family SLC25: identification, properties and physiopathology.

Authors: Ferdinando Palmieri
Journal: Mol Aspects Med Date: 2012-12-23

Review 3. Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation.

Authors: Sharanya Sivanand; Isabella Viney; Kathryn E Wellen
Journal: Trends Biochem Sci Date: 2017-11-23 Impact factor: 13.807

Review 4. From Krebs to clinic: glutamine metabolism to cancer therapy.

Authors: Brian J Altman; Zachary E Stine; Chi V Dang
Journal: Nat Rev Cancer Date: 2016-07-29 Impact factor: 60.716

5. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism.

Authors: Gregory A Wyant; Gyan Prakash; Nora Kory; Jelmi Uit de Bos; Francesca Bottanelli; Michael E Pacold; Sze Ham Chan; Caroline A Lewis; Tim Wang; Heather R Keys; Yang Eric Guo; David M Sabatini
Journal: Science Date: 2018-11-16 Impact factor: 47.728

6. A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells.

Authors: Hee Chan Yoo; Seung Joon Park; Miso Nam; Juwon Kang; Kibum Kim; Joo Hye Yeo; Joon-Ki Kim; Yunkyung Heo; Hee Seung Lee; Myeong Youl Lee; Chang Woo Lee; Jong Soon Kang; Yun-Hee Kim; Jinu Lee; Junjeong Choi; Geum-Sook Hwang; Seungmin Bang; Jung Min Han
Journal: Cell Metab Date: 2019-12-19 Impact factor: 27.287

7. SLC19A1 transports immunoreactive cyclic dinucleotides.

Authors: Rutger D Luteijn; Shivam A Zaver; Benjamin G Gowen; Stacia K Wyman; Nick E Garelis; Liberty Onia; Sarah M McWhirter; George E Katibah; Jacob E Corn; Joshua J Woodward; David H Raulet
Journal: Nature Date: 2019-09-11 Impact factor: 49.962

Review 8. Fundamentals of cancer metabolism.

Authors: Ralph J DeBerardinis; Navdeep S Chandel
Journal: Sci Adv Date: 2016-05-27 Impact factor: 14.136

9. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates.

Authors: Zhou Yu; Lauren E Surface; Chong Yon Park; Max A Horlbeck; Gregory A Wyant; Monther Abu-Remaileh; Timothy R Peterson; David M Sabatini; Jonathan S Weissman; Erin K O'Shea
Journal: Elife Date: 2018-05-10 Impact factor: 8.140

Review 10. Mitochondrial Carriers for Aspartate, Glutamate and Other Amino Acids: A Review.

Authors: Magnus Monné; Angelo Vozza; Francesco Massimo Lasorsa; Vito Porcelli; Ferdinando Palmieri
Journal: Int J Mol Sci Date: 2019-09-10 Impact factor: 5.923