| Literature DB >> 27492215 |
Brian J Altman1,2,3, Zachary E Stine1,2,3, Chi V Dang1,2,3.
Abstract
The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.Entities:
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Year: 2016 PMID： 27492215 PMCID： PMC5484415 DOI： 10.1038/nrc.2016.71
Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716