| Literature DB >> 31866298 |
Cathia Rausch1, Florian D Hastert1, M Cristina Cardoso2.
Abstract
Genomic DNA is modified in a postreplicative manner and several modifications, the enzymes responsible for their deposition as well as proteins that read these modifications, have been described. Here, we focus on the impact of DNA modifications on the DNA helix and review the writers and readers of cytosine modifications and how they interplay to shape genome composition, stability, and function.Entities:
Keywords: 5-carboxylcytosine; 5-formylcytosine; 5-hydroxymethylcytosine; 5-methylcytosine; 5caC; 5fC; 5hmC; 5mC; C; CGI; CXXC; CpG; CpG island; Cysteine/X/X/cysteine zinc finger motif; Cytosine; Cytosine-phosphate-guanine dinucleotide; DNA helix stability; DNA methylation readers; DNA methyltransferase; DNA modification writers; DNA modifications; DNMT; ES cells; Embryonic stem cells; ID; Intervening domain; MBD; Melting temperature; Methyl-CpG-binding domain; T(m); TET; TRD; Ten-eleven translocation; Transcriptional repression domain; chromatin
Year: 2019 PMID： 31866298 DOI： 10.1016/j.jmb.2019.12.018
Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469