Yuxiao Sun1, Jifeng Yan2, Jiliang Zhang2, Aifeng Wang2, Jie Zou2, Chuanyu Gao3. 1. Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou 450003, People's Republic of China; Fuwai Central China Cardiovascular Hospital, Zhengzhou 450003, People's Republic of China; People's Hospital of Zhengzhou University, Zhengzhou 450003, People's Republic of China; Henan Provincial Key Laboratory for Control of Coronary Heart Disease, Zhengzhou 450003, People's Republic of China. 2. Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou 450003, People's Republic of China; Fuwai Central China Cardiovascular Hospital, Zhengzhou 450003, People's Republic of China; People's Hospital of Zhengzhou University, Zhengzhou 450003, People's Republic of China. 3. Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou 450003, People's Republic of China; Fuwai Central China Cardiovascular Hospital, Zhengzhou 450003, People's Republic of China; People's Hospital of Zhengzhou University, Zhengzhou 450003, People's Republic of China; Henan Provincial Key Laboratory for Control of Coronary Heart Disease, Zhengzhou 450003, People's Republic of China. Electronic address: gcy@163.com.
Abstract
BACKGROUND: Coronary heart disease (CHD) is a common chronic inflammatory disease. Interleukin (IL)-7/IL-7R has been reported to be involved in the development of CHD. However, the relationship between IL-7/7R genetic polymorphisms and CHD among the Han Chinese population remains unclear. METHODS: To examine whether IL-7/7R variants contributed to CHD, six single-nucleotide polymorphisms (SNPs) were genotyped by using the Agena MassARRAY platform in 499 CHD patients and 496 controls. Logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). The linkage disequilibrium was analyzed using Haploview software. The association between clinical parameters and IL-7/7R polymorphisms was determined by a one-way ANOVA. RESULTS: IL-7R rs969129 G (OR = 1.20, 95% CI: 1.00-1.43, p = 0.047) allele and GG (OR = 1.45, 95% CI: 1.01-2.08, p = 0.044) genotype carriers had a higher risk for CHD. IL-7R haplotype "ACAG" (OR = 1.43, 95% CI: 1.09-1.87, p = 0.010) conferred an increased CHD risk. Rs969129, rs6451231, and rs117173992 were related to CHD susceptibility in males and/or the subgroup of individuals aged >61 years. IL-7R rs969129, rs10053847, rs6451231, and rs118137916 variants were associated with diabetes in patients with CHD. Moreover, rs969129, rs6451231, and rs117173992 were associated with high-density lipoprotein cholesterol (HDL-C) concentrations, whereas rs118137916 and rs10053847 were associated with low-density lipoprotein cholesterol (LDL-C) levels (p < 0.05). CONCLUSION: IL-7/7R variants were related to the genetic predisposition of CHD in the Chinese Han population. These findings increase our knowledge regarding the effect of IL-7/7R on CHD.
BACKGROUND:Coronary heart disease (CHD) is a common chronic inflammatory disease. Interleukin (IL)-7/IL-7R has been reported to be involved in the development of CHD. However, the relationship between IL-7/7R genetic polymorphisms and CHD among the Han Chinese population remains unclear. METHODS: To examine whether IL-7/7R variants contributed to CHD, six single-nucleotide polymorphisms (SNPs) were genotyped by using the Agena MassARRAY platform in 499 CHDpatients and 496 controls. Logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). The linkage disequilibrium was analyzed using Haploview software. The association between clinical parameters and IL-7/7R polymorphisms was determined by a one-way ANOVA. RESULTS:IL-7Rrs969129 G (OR = 1.20, 95% CI: 1.00-1.43, p = 0.047) allele and GG (OR = 1.45, 95% CI: 1.01-2.08, p = 0.044) genotype carriers had a higher risk for CHD. IL-7R haplotype "ACAG" (OR = 1.43, 95% CI: 1.09-1.87, p = 0.010) conferred an increased CHD risk. Rs969129, rs6451231, and rs117173992 were related to CHD susceptibility in males and/or the subgroup of individuals aged >61 years. IL-7Rrs969129, rs10053847, rs6451231, and rs118137916 variants were associated with diabetes in patients with CHD. Moreover, rs969129, rs6451231, and rs117173992 were associated with high-density lipoprotein cholesterol (HDL-C) concentrations, whereas rs118137916 and rs10053847 were associated with low-density lipoprotein cholesterol (LDL-C) levels (p < 0.05). CONCLUSION:IL-7/7R variants were related to the genetic predisposition of CHD in the Chinese Han population. These findings increase our knowledge regarding the effect of IL-7/7R on CHD.