Literature DB >> 31859552

PRACTICE VARIATION IN THE MANAGEMENT OF GIRLS AND BOYS WITH DELAYED PUBERTY.

Jia Zhu, Henry A Feldman, Erica A Eugster, Patricia Y Fechner, Leena Nahata, Paul S Thornton, Yee-Ming Chan.   

Abstract

Objective: Delayed puberty is a common condition, and typical management includes "watchful waiting" and/or sex-steroid therapy. We sought to characterize treatment practices and to assess provider comfort with the management of delayed puberty in girls and boys.
Methods: A national survey of pediatric endocrine providers assessed definitions of delayed puberty, practices around sex-steroid therapy, reasons for treatment, and comfort in managing delayed puberty in girls and boys.
Results: Of 184 respondents (12% participation rate), 64% and 71% used the traditional age cutoffs for defining delayed puberty of 13 years for girls and 14 years for boys, respectively. Nearly half (45%) of providers would treat boys relatively earlier than girls, compared to 18% who would treat girls relatively earlier (P<.0001). Providers were more likely to cite bone density as a reason to treat girls and alleviating patient and parental distress, accelerating growth, and "jump starting" puberty as reasons to treat boys. Greater experience in endocrine practice was associated with greater comfort managing delayed puberty in both boys and girls. Approximately 80% of providers agreed that clinical guidelines are needed for the management of delayed puberty.
Conclusion: There is a high degree of variability in the clinical management of delayed puberty, and our results suggest that providers are more hesitant to treat girls compared to boys and have different reasons for treating each. It remains to be determined if these discrepancies in treatment are justified by biologic differences between girls and boys or represent nonevidence-based disparities in care. Abbreviation: U.S. = United States.

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Year:  2019        PMID: 31859552      PMCID: PMC7133108          DOI: 10.4158/EP-2019-0344

Source DB:  PubMed          Journal:  Endocr Pract        ISSN: 1530-891X            Impact factor:   3.443


  36 in total

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Authors:  Ines L Sedlmeyer; Joel N Hirschhorn; Mark R Palmert
Journal:  J Clin Endocrinol Metab       Date:  2002-12       Impact factor: 5.958

Review 2.  Clinical practice. Delayed puberty.

Authors:  Mark R Palmert; Leo Dunkel
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3.  Pubertal development timing in urban Chinese boys.

Authors:  H-M Ma; S-K Chen; R-M Chen; C Zhu; F Xiong; T Li; W Wang; G-L Liu; X-P Luo; L Liu; M-L Du
Journal:  Int J Androl       Date:  2011-06-09

4.  National estimates of the timing of sexual maturation and racial differences among US children.

Authors:  Shumei S Sun; Christine M Schubert; William Cameron Chumlea; Alex F Roche; Howard E Kulin; Peter A Lee; John H Himes; Alan S Ryan
Journal:  Pediatrics       Date:  2002-11       Impact factor: 7.124

5.  Congenital hypogonadotropic hypogonadism, functional hypogonadotropism or constitutional delay of growth and puberty? An analysis of a large patient series from a single tertiary center.

Authors:  Tero Varimo; Päivi J Miettinen; Johanna Känsäkoski; Taneli Raivio; Matti Hero
Journal:  Hum Reprod       Date:  2016-12-06       Impact factor: 6.918

Review 6.  Delayed puberty in the female patient.

Authors:  Gylynthia E Trotman
Journal:  Curr Opin Obstet Gynecol       Date:  2016-10       Impact factor: 1.927

7.  Recent changes in pubertal timing in healthy Danish boys: associations with body mass index.

Authors:  Kaspar Sørensen; Lise Aksglaede; Jørgen Holm Petersen; Anders Juul
Journal:  J Clin Endocrinol Metab       Date:  2009-11-19       Impact factor: 5.958

8.  Final height in girls with untreated constitutional delay in growth and puberty.

Authors:  E C Crowne; S M Shalet; W H Wallace; D M Eminson; D A Price
Journal:  Eur J Pediatr       Date:  1991-08       Impact factor: 3.183

9.  Secondary sexual characteristics in boys: data from the Pediatric Research in Office Settings Network.

Authors:  Marcia E Herman-Giddens; Jennifer Steffes; Donna Harris; Eric Slora; Michael Hussey; Steven A Dowshen; Richard Wasserman; Janet R Serwint; Lynn Smitherman; Edward O Reiter
Journal:  Pediatrics       Date:  2012-10-20       Impact factor: 7.124

10.  Timing of maturation and predictors of Tanner stage transitions in boys enrolled in a contemporary British cohort.

Authors:  Carolyn Monteilh; Stephanie Kieszak; W Dana Flanders; Mildred Maisonet; Carol Rubin; Adrianne K Holmes; Jon Heron; Jean Golding; Michael A McGeehin; Michele Marcus
Journal:  Paediatr Perinat Epidemiol       Date:  2010-11-05       Impact factor: 3.980

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  2 in total

1.  Fertility Counseling Practices for Patients with Turner Syndrome in Pediatric Endocrine Clinics: Results of a Pediatric Endocrine Society Survey.

Authors:  Charleen I Theroux; Victoria Elliott; Shanlee Davis; Canice E Crerand; Jessica Kremen; Amy Tishelman; Christa Hutaff-Lee; Leena Nahata
Journal:  Horm Res Paediatr       Date:  2022-04-12       Impact factor: 4.275

2.  Delayed puberty in boys in central Sweden: an observational study on diagnosing and management in clinical practice.

Authors:  Maria Rodanaki; Eva Rask; Maria Lodefalk
Journal:  BMJ Open       Date:  2022-02-03       Impact factor: 2.692

  2 in total

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