Literature DB >> 3185748

Positive inotropic effects of calcium channel antagonists are not necessarily caused by partial calcium channel agonism.

N C Punt1, F T van Amsterdam, M M Goddijn, M Haas, J Zaagsma.   

Abstract

Recently it has been reported that some dihydropyridine calcium channel antagonists (nifedipine, nimodipine, nitrendipine) are able to produce positive inotropic effects in isolated perfused guinea pig hearts. We studied the effects of nifedipine in isolated perfused paced rat hearts under constant pressure and constant flow perfusion conditions. We found that nifedipine is able to produce a positive inotropic effect under constant pressure conditions but not under constant flow conditions. We conclude that nifedipine does not have partial calcium channel agonistic properties and that the positive inotropic effect seen under constant pressure conditions is a result of the vasodilating properties of the drug. Positive inotropic effects caused by vasodilatation can be explained by the "garden-hose-effect".

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Year:  1988        PMID： 3185748     DOI： 10.1007/bf00174873

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  19 in total

1.  The positive inotropic action of the nifedipine analogue, Bay K 8644, in guinea-pig and rat isolated cardiac preparations.

Authors:  M Finet; T Godfraind; G Khoury
Journal:  Br J Pharmacol       Date:  1985-09       Impact factor: 8.739

2.  The positive inotropic effect of felodipine in isovolumically beating dog heart.

Authors:  K Pettersson; M I Noble; J A Björkman; J Hynd; A J Drake-Holland
Journal:  J Cardiovasc Pharmacol       Date:  1987       Impact factor: 3.105

Review 3.  Calcium-agonists.

Authors:  M Bechem; M Schramm
Journal:  J Mol Cell Cardiol       Date:  1987-05       Impact factor: 5.000

4.  The importance of the perfusion pressure in the coronary arteries for the contractility and the oxygen consumption of the heart.

Authors:  G Arnold; F Kosche; E Miessner; A Neitzert; W Lochner
Journal:  Pflugers Arch Gesamte Physiol Menschen Tiere       Date:  1968

5.  Calcium channel modulation: ability to inhibit or promote calcium influx resides in the same dihydropyridine molecule.

Authors:  G Thomas; R Gross; M Schramm
Journal:  J Cardiovasc Pharmacol       Date:  1984 Nov-Dec       Impact factor: 3.105

6.  Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists.

Authors:  P Hess; J B Lansman; R W Tsien
Journal:  Nature       Date:  1984 Oct 11-17       Impact factor: 49.962

7.  Effects of coronary blood flow and perfusion pressure on left ventricular contractility in dogs.

Authors:  R M Abel; R L Reis
Journal:  Circ Res       Date:  1970-12       Impact factor: 17.367

8.  Problem of measuring the positive inotropic property of a vasodilating drug: an illustration using felodipine.

Authors:  A J Drake-Holland; S Pugh; M I Noble; C Mills
Journal:  Cardiovasc Res       Date:  1987-09       Impact factor: 10.787

9.  Stereoisomers of calcium antagonists discriminate between coronary vascular and myocardial sites.

Authors:  F T van Amsterdam; J Zaagsma
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-02       Impact factor: 3.000

10.  Dynamic and kinetic differences of the vascular and myocardial effects of calcium antagonists in the rat heart.

Authors:  F T van Amsterdam; M Haas; J Zaagsma
Journal:  J Cardiovasc Pharmacol       Date:  1987-05       Impact factor: 3.105
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  6 in total

1.  Differences between negative inotropic and vasodilator effects of calcium antagonists acting on extra- and intracellular calcium movements in rat and guinea-pig cardiac preparations.

Authors:  J G Hugtenburg; M J Mathy; H W Boddeke; J J Beckeringh; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-11       Impact factor: 3.000

2.  Stereoisomers of BAY K 8644 show opposite activities in the normal and ischaemic rat heart. A comparison with nifedipine.

Authors:  F T van Amsterdam; N C Punt; M Haas; M S van Amsterdam-Magnoni; J Zaagsma
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-06       Impact factor: 3.000

3.  Protection by verapamil and nifedipine against ischaemia-induced loss of [3H]-(+)-PN 200-110 binding sites in the rat heart.

Authors:  F T van Amsterdam; M S van Amsterdam-Magnoni; M Haas; N C Punt; J Zaagsma
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990 Jan-Feb       Impact factor: 3.000

4.  Pancreatic surgery, not pancreatitis, is the primary cause of diabetes after acute fulminant pancreatitis.

Authors:  J Eriksson; M Doepel; E Widén; L Halme; A Ekstrand; L Groop; K Höckerstedt
Journal:  Gut       Date:  1992-06       Impact factor: 23.059

5.  Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.

Authors:  Y Nasa; K Ichihara; R Yoshida; Y Abiko
Journal:  Br J Pharmacol       Date:  1992-03       Impact factor: 8.739

6.  Effect of changes in aortic pressure and in coronary arterial pressure on left ventricular geometry and function Anrep vs. gardenhose effect.

Authors:  J D Schipke; I Stocks; U Sunderdiek; G Arnold
Journal:  Basic Res Cardiol       Date:  1993 Nov-Dec       Impact factor: 17.165
  6 in total

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