Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists.

Literature DB >> 6207437

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists.

Abstract

Single cardiac transmembranous Ca channels have three modes of gating behaviour in the absence of drugs, expressed as current records with brief openings (mode 1), with no openings because of channel unavailability (mode 0 or null mode) and with long-lasting openings and very brief closings that appear only rarely (mode 2). The dihydropyridine Ca agonist Bay K 8644 enhances Ca channel current by promoting mode 2, while the Ca antagonists nitrendipine and nimodipine inhibit the current by favouring mode 0.

Entities: Chemical

Mesh：

Substances：

Year: 1984 PMID： 6207437 DOI： 10.1038/311538a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

Keyword Cloud
Cited

432 in total

Review 1. Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans.

Authors: L S Satin
Journal: Endocrine Date: 2000-12 Impact factor: 3.633

2. G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels.

Authors: Y Chen-Izu; R P Xiao; L T Izu; H Cheng; M Kuschel; H Spurgeon; E G Lakatta
Journal: Biophys J Date: 2000-11 Impact factor: 4.033

3. A model of the L-type Ca2+ channel in rat ventricular myocytes: ion selectivity and inactivation mechanisms.

Authors: L Sun; J S Fan; J W Clark; P T Palade
Journal: J Physiol Date: 2000-11-15 Impact factor: 5.182

4. The alpha 1-subunit of smooth muscle Ca(2+) channel preserves multiple open states induced by depolarization.

Authors: S Nakayama; N Klugbauer; Y Kabeya; L M Smith; F Hofmann; M Kuzuya
Journal: J Physiol Date: 2000-07-01 Impact factor: 5.182

5. Ca2+ transport properties and determinants of anomalous mole fraction effects of single voltage-gated Ca2+ channels in hair cells from bullfrog saccule.

Authors: Adrian Rodriguez-Contreras; Wolfgang Nonner; Ebenezer N Yamoah
Journal: J Physiol Date: 2002-02-01 Impact factor: 5.182

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists.

Review 1. Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans.

2. G(i)-dependent localization of beta(2)-adrenergic receptor signaling to L-type Ca(2+) channels.

3. A model of the L-type Ca2+ channel in rat ventricular myocytes: ion selectivity and inactivation mechanisms.

4. The alpha 1-subunit of smooth muscle Ca(2+) channel preserves multiple open states induced by depolarization.

5. Ca2+ transport properties and determinants of anomalous mole fraction effects of single voltage-gated Ca2+ channels in hair cells from bullfrog saccule.

6. Kurtoxin, a gating modifier of neuronal high- and low-threshold ca channels.

7. Direct measurement of single-channel Ca(2+) currents in bullfrog hair cells reveals two distinct channel subtypes.

8. Two-dimensional kinetic analysis suggests nonsequential gating of mechanosensitive channels in Xenopus oocytes.

9. Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells.

10. L-Type calcium channels mediate calcium oscillations in early postnatal Purkinje neurons.