| Literature DB >> 31853902 |
Gulladawan Jan-On1,2, Weerapon Sangartit1,2, Poungrat Pakdeechote1,2, Veerapol Kukongviriyapan3, Ketmanee Senaphan4, Orachorn Boonla5, Chakree Thongraung6, Upa Kukongviriyapan7,8.
Abstract
Rice bran hydrolysates contain highly nutritional proteins and beneficial phytochemicals. Sang-Yod rice bran hydrolysates (SRH) extracted from red pigmented rice is a rich source of nutrients and phenolic compounds. The present study evaluated the antihypertensive effect of SRH and its safety in Sprague-Dawley rats. Hypertension was induced in male rats by administration of L-NAME (50 mg/kg/day) in drinking water for three weeks, and the antihypertensive effect of SRH was evaluated. Treatment of SRH (250 or 500 mg/kg) significantly reduced arterial blood pressure and improved hemodynamic parameters. The antihypertensive effect was associated with decreased oxidative stress, suppressed p47phox NADPH oxidase expression, increased nitric oxide bioavailability and decreased angiotensin II level and ACE activity. The SRH was shown to be safe after feeding male and female rats with a rodent diet containing 1.5% SRH for 90 days. Overall, these findings suggest that SRH is safe and may help to prevent hypertension.Entities:
Keywords: Hypertension; L-NAME; Nitric oxide; Oxidative stress; Sang-Yod rice bran hydrolysates; Subchronic toxicity
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Year: 2020 PMID： 31853902 DOI： 10.1007/s11130-019-00789-9
Source DB: PubMed Journal: Plant Foods Hum Nutr ISSN： 0921-9668 Impact factor: 3.921