| Literature DB >> 31848716 |
Mingxuan Ma1,2, Ying Xi1,2, Yingxiang Du3,4, Jiangxia Yang1,2, Xiaofei Ma1,2, Cheng Chen1,2.
Abstract
An electrochromatographic capillary was modified with graphene oxide (GO), and the coating was characterized by scanning electron microscopy, energy dispersive X-ray spectrometry, and Fourier transform infrared spectra. By utilizing maltodextrin (MD) as the chiral selector, the basic chiral drugs nefopam (NEF), amlodipine (AML), citalopram hydrobromide (CIT), econazole (ECO), ketoconazole (KET) and cetirizine hydrochloride (CET) can be enantiomerically separated on this CEC. Compared with an uncoated silica capillary, the resolutions are markedly improved (AML: 0.32 → 1.45; ECO: 0.55 → 1.89; KET: 0.88 → 4.77; CET: 0.81 → 2.46; NEF: 1.46 → 2.83; CIT: 1.77 → 4.38). Molecular modeling was applied to demonstrate the mechanism of enantioseparation, which showed a good agreement with the experimental results. Graphical abstractSchematic representation of the preparation of graphene oxide-modified capillary (GO@capillary) for enantioseparation of drug enantiomers. The monolayered GO was used as the coating of the GO@capillary. Then the capillary was applied to construct capillary electrochromatography system with maltodextrin for separation of basic chiral drugs.Entities:
Keywords: Basic drugs; Capillary coating; Capillary electrophoresis; Chiral separation; GO; GO coating; MD; Molecular modeling; Open-tubular capillary
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Year: 2019 PMID： 31848716 DOI： 10.1007/s00604-019-4037-x
Source DB: PubMed Journal: Mikrochim Acta ISSN： 0026-3672 Impact factor: 5.833