Keiko Yamada1,2,3, Takashi Kimura4, Satoyo Ikehara5, Meishan Cui5, Yasuhiko Kubota6, Kenta Wakaizumi7,8, Takashi Takeda9, Hiroyasu Iso5,10. 1. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. keiko-yamada@umin.org. 2. Department of Psychology, McGill University, 2001 McGill College, Montreal, QC, H3A 1G1, Canada. keiko-yamada@umin.org. 3. Department of Anesthesiology and Pain Medicine, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. keiko-yamada@umin.org. 4. Department of Public Health, Hokkaido University Graduate School of Medicine, 7, Kita15-jo Nishi, Kita-ku, Sapporo, 060-8638, Japan. 5. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. 6. Osaka Center for Cancer and Cardiovascular Diseases Prevention, 1-6-107 Morinomiya, Jyoto-ku, Osaka, 536-8588, Japan. 7. Shirley Ryan AbilityLab, 355 East Erie, Chicago, IL, 60611, USA. 8. Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, 710 N Lake Shore Dr, Chicago, IL, 60611, USA. 9. Division of Women's Health, Research Institute of Traditional Asian Medicine, Kindai University, 377-2 Ohno-higashi, Osaka-sayama, Osaka, 589-8511, Japan. 10. Department of Public Health Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.
Abstract
PURPOSE: Analgesic medication epidemic during pregnancy is an important issue in Western countries. However, no large epidemiological study involving pregnant women with pain and their medication use has been conducted in Japan. This study examined the current situation of medication use for non-cancer pain during the perinatal period in Japan using national cohort data. METHODS: We analyzed 94,649 pregnant women who completed a self-report questionnaire investigating bodily pain and an interview-based medication use survey. Medication use before and during pregnancy and new medication administration/discontinuation during pregnancy were compared between women with and without pain during pregnancy using multivariable covariance analysis. RESULTS: Mild pain was reported by 50.4% of pregnant women in the first trimester (survey 1) and 61.8% in the second/third trimester (survey 2). Moderate-to-severe pain was reported by 15.4% of women in survey 1 and 22.4% in survey 2. In survey 1, 6.2% of women used prescribed analgesics and 1.6% used over-the-counter analgesics. In survey 2, prescribed and over the counter analgesics were used by 12.2% and 0.8% of women, respectively. Other pain-related medications were rarely used (< 1.0%). Pregnant women with moderate-to-severe pain showed a lower proportion of discontinuation of analgesics and a higher proportion of new administration of prescription and transdermal analgesics compared with those without pain. CONCLUSIONS: Although a large proportion of pregnant women experience pain, medication use for pain during pregnancy is low in Japan compared with Western countries (50-60%). Adequate treatment or support may be necessary for pregnant women experiencing pain in Japan.
PURPOSE: Analgesic medication epidemic during pregnancy is an important issue in Western countries. However, no large epidemiological study involving pregnant women with pain and their medication use has been conducted in Japan. This study examined the current situation of medication use for non-cancer pain during the perinatal period in Japan using national cohort data. METHODS: We analyzed 94,649 pregnant women who completed a self-report questionnaire investigating bodily pain and an interview-based medication use survey. Medication use before and during pregnancy and new medication administration/discontinuation during pregnancy were compared between women with and without pain during pregnancy using multivariable covariance analysis. RESULTS: Mild pain was reported by 50.4% of pregnant women in the first trimester (survey 1) and 61.8% in the second/third trimester (survey 2). Moderate-to-severe pain was reported by 15.4% of women in survey 1 and 22.4% in survey 2. In survey 1, 6.2% of women used prescribed analgesics and 1.6% used over-the-counter analgesics. In survey 2, prescribed and over the counter analgesics were used by 12.2% and 0.8% of women, respectively. Other pain-related medications were rarely used (< 1.0%). Pregnant women with moderate-to-severe pain showed a lower proportion of discontinuation of analgesics and a higher proportion of new administration of prescription and transdermal analgesics compared with those without pain. CONCLUSIONS: Although a large proportion of pregnant women experience pain, medication use for pain during pregnancy is low in Japan compared with Western countries (50-60%). Adequate treatment or support may be necessary for pregnant women experiencing pain in Japan.
Entities:
Keywords:
Drug utilization; Medication adherence; Pain; Pain management; Pregnant women
Authors: Adley Tsang; Michael Von Korff; Sing Lee; Jordi Alonso; Elie Karam; Matthias C Angermeyer; Guilherme Luiz Guimaraes Borges; Evelyn J Bromet; K Demytteneare; Giovanni de Girolamo; Ron de Graaf; Oye Gureje; Jean-Pierre Lepine; Josep Maria Haro; Daphna Levinson; Mark A Oakley Browne; Jose Posada-Villa; Soraya Seedat; Makoto Watanabe Journal: J Pain Date: 2008-07-07 Impact factor: 5.820
Authors: Phoebe G Thorpe; Suzanne M Gilboa; Sonia Hernandez-Diaz; Jennifer Lind; Janet D Cragan; Gerald Briggs; Sandra Kweder; Jan M Friedman; Allen A Mitchell; Margaret A Honein Journal: Pharmacoepidemiol Drug Saf Date: 2013-07-29 Impact factor: 2.890