Fabio Conforti1, Laura Pala2, Eleonora Pagan3, Vincenzo Bagnardi3, Paola Zagami2, Lorenzo Spaggiari4, Chiara Catania5, Johan Vansteenkiste6, Giuseppe Giaccone7, Tommaso De Pas2. 1. Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, Milan, Italy. Electronic address: fabio.conforti@ieo.it. 2. Division of Medical Oncology for Melanoma, Sarcoma, and Rare Tumors, IEO, European Institute of Oncology IRCCS, Milan, Italy. 3. Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy. 4. Division of Thoracic Surgery, IEO European Institute of Oncology, IRCCS, University of Milan, Milan, Italy; Department of Oncology and Hematology (DIPO), School of Medicine, University of Milan, Milan, Italy. 5. Division of Thoracic Oncology, IEO, European Institute of Oncology IRCCS, 20141, Milan, Italy. 6. Department of Respiratory Oncology, University Hospital KU Leuven, Leuven, Belgium. 7. Department of Oncology, Weill Cornel Medicine, New York, USA.
Abstract
BACKGROUND: Limited evidence is available on effectiveness of clinicoradiological follow-up of early-stage NSCLC patients. MAGRIT was a phase III adjuvant RCT conducted in surgically resected stage IB-IIIA NSCLC patients, in which all participants had a prospectively defined intensive clinicoradiological follow-up. METHODS: At patient-level data, we analyzed detection modality of disease recurrences and new primary lung cancer (i.e. detected by clinicoradiological scheduled exams versus by interim unscheduled exams), features associated with higher risk of locoregional and/or distant recurrence, and recurrence rates over time. RESULTS: In the 2261 patients studied, there was a significant association between the type of recurrence and the modality of detection: 88.4% (95% CI, 84%-91%) of the locoregional recurrences and 93.2% (95% CI, 84%-99%) of the new primary lung cancers were detected by scheduled exams, whereas this was only 68.7% (95% CI, 65%-73%) for distant metastases (p < 0.001). Survival of patients with locoregional recurrence or new primary lung cancer detected by scheduled exams was significantly better as compared with those detected by unscheduled exams (HR 0.56, 95% CI 0.36-0.87; p = 0.01). Survival was similarly poor in patients with distant recurrences, both with scheduled and unscheduled detection (3-year survival after recurrence 22.0% and 21.8%, respectively). Recurrence rate was the highest in the first 18 months after surgery-with a peak between month 6 and 12-decreasing thereafter. The hazard of a second primary lung cancer was constant over time. CONCLUSION: Intensive follow-up is effective in detecting locoregional recurrences and second primary lung cancers, with impact on patients' survival but did not influence the detection of distant recurrences.
BACKGROUND: Limited evidence is available on effectiveness of clinicoradiological follow-up of early-stage NSCLCpatients. MAGRIT was a phase III adjuvant RCT conducted in surgically resected stage IB-IIIA NSCLCpatients, in which all participants had a prospectively defined intensive clinicoradiological follow-up. METHODS: At patient-level data, we analyzed detection modality of disease recurrences and new primary lung cancer (i.e. detected by clinicoradiological scheduled exams versus by interim unscheduled exams), features associated with higher risk of locoregional and/or distant recurrence, and recurrence rates over time. RESULTS: In the 2261 patients studied, there was a significant association between the type of recurrence and the modality of detection: 88.4% (95% CI, 84%-91%) of the locoregional recurrences and 93.2% (95% CI, 84%-99%) of the new primary lung cancers were detected by scheduled exams, whereas this was only 68.7% (95% CI, 65%-73%) for distant metastases (p < 0.001). Survival of patients with locoregional recurrence or new primary lung cancer detected by scheduled exams was significantly better as compared with those detected by unscheduled exams (HR 0.56, 95% CI 0.36-0.87; p = 0.01). Survival was similarly poor in patients with distant recurrences, both with scheduled and unscheduled detection (3-year survival after recurrence 22.0% and 21.8%, respectively). Recurrence rate was the highest in the first 18 months after surgery-with a peak between month 6 and 12-decreasing thereafter. The hazard of a second primary lung cancer was constant over time. CONCLUSION: Intensive follow-up is effective in detecting locoregional recurrences and second primary lung cancers, with impact on patients' survival but did not influence the detection of distant recurrences.
Authors: Andreas Domen; Christophe Deben; Ines De Pauw; Christophe Hermans; Hilde Lambrechts; Jasper Verswyvel; Vasiliki Siozopoulou; Patrick Pauwels; Marco Demaria; Mick van de Wiel; Annelies Janssens; Jeroen M H Hendriks; Paul Van Schil; Jan B Vermorken; Timon Vandamme; Hans Prenen; Marc Peeters; Filip Lardon; An Wouters Journal: Transl Lung Cancer Res Date: 2022-08