Literature DB >> 3182820

Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria.

E E Kaufman1, T Nelson, H M Fales, D M Levin.   

Abstract

A transhydrogenase that catalyzes the oxoacid-dependent oxidation of specific hydroxyacids has been found in rat kidney, liver, and brain. The hydroxyacids that have been found to be substrates for this enzyme are gamma-hydroxybutyrate, D-alpha-hydroxyglutarate, and L-beta-hydroxybutyrate. The oxoacids that are the best substrates for this enzyme are alpha-ketoglutarate and succinic semialdehyde; alpha-ketoadipate and oxalacetate are also substrates. This enzyme is located in the mitochondrial fraction of the cell and is not dependent on added NAD+ or NADP+.

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Year:  1988        PMID： 3182820

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  25 in total

Review 1.  Succinic semialdehyde dehydrogenase: biochemical-molecular-clinical disease mechanisms, redox regulation, and functional significance.

Authors:  Kyung-Jin Kim; Phillip L Pearl; Kimmo Jensen; O Carter Snead; Patrizia Malaspina; Cornelis Jakobs; K Michael Gibson
Journal:  Antioxid Redox Signal       Date:  2011-04-10       Impact factor: 8.401

2.  Determination of the GABA analogue succinic semialdehyde in urine and cerebrospinal fluid by dinitrophenylhydrazine derivatization and liquid chromatography-tandem mass spectrometry: application to SSADH deficiency.

Authors:  E A Struys; E E W Jansen; K M Gibson; C Jakobs
Journal:  J Inherit Metab Dis       Date:  2005       Impact factor: 4.982

3.  Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias.

Authors:  E A Struys; N M Verhoeven; H J Ten Brink; W V Wickenhagen; K M Gibson; C Jakobs
Journal:  J Inherit Metab Dis       Date:  2005       Impact factor: 4.982

Review 4.  An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP(+)-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway.

Authors:  E E Kaufman; T Nelson
Journal:  Neurochem Res       Date:  1991-09       Impact factor: 3.996

Review 5.  Metabolite damage and its repair or pre-emption.

Authors:  Carole L Linster; Emile Van Schaftingen; Andrew D Hanson
Journal:  Nat Chem Biol       Date:  2013-02       Impact factor: 15.040

6.  Oxidation of the cyclic ethers 1,4-dioxane and tetrahydrofuran by a monooxygenase in two Pseudonocardia species.

Authors:  Christopher M Sales; Ariel Grostern; Juanito V Parales; Rebecca E Parales; Lisa Alvarez-Cohen
Journal:  Appl Environ Microbiol       Date:  2013-10-04       Impact factor: 4.792

7.  Effects of 1,4-butanediol administration on oxidative stress in rat brain: study of the neurotoxicity of gamma-hydroxybutyric acid in vivo.

Authors:  Angela M Sgaravatti; Alessandra S Magnusson; Amanda S Oliveira; Caroline P Mescka; Fernanda Zanin; Mirian B Sgarbi; Carolina D Pederzolli; Angela T S Wyse; Clóvis M D Wannmacher; Moacir Wajner; Carlos S Dutra-Filho
Journal:  Metab Brain Dis       Date:  2009-03-19       Impact factor: 3.584

8.  Identification of a dehydrogenase acting on D-2-hydroxyglutarate.

Authors:  Younes Achouri; Gaëtane Noël; Didier Vertommen; Mark H Rider; Maria Veiga-Da-Cunha; Emile Van Schaftingen
Journal:  Biochem J       Date:  2004-07-01       Impact factor: 3.857

Review 9.  Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency.

Authors:  Patrizia Malaspina; Matthew J Picklo; C Jakobs; O Carter Snead; K Michael Gibson
Journal:  Hum Genomics       Date:  2009-01       Impact factor: 4.639

10.  Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during development.

Authors:  Erwin E W Jansen; Eduard Struys; Cornelis Jakobs; Elizabeth Hager; O Carter Snead; K Michael Gibson
Journal:  BMC Dev Biol       Date:  2008-11-28       Impact factor: 1.978
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