Literature DB >> 31826708

ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses.

Laura Powell1, Youhani H Samarakoon2,3, Shehab Ismail2,3, John A Sayer1,4,5.   

Abstract

The primary cilium and the immunological synapse are both specialized functional plasma membrane domains that share several similarities. Signalling output of membrane domains is regulated, spatially and temporally, by segregating and focusing lipids and proteins. ARL3, a small GTPase, plays a major role in concentrating lipid-modified proteins in both the immunological synapse and the primary cilia. Here in this review we will introduce the role of ARL3 in health and disease and its role in polarizing signalling at the primary cilia and immunological synapses.

Entities:  

Keywords:  ARL3; Primary cilia; cargo; immune synapse; signalling

Mesh：

Substances：

Year:  2019        PMID： 31826708      PMCID： PMC7939558          DOI： 10.1080/21541248.2019.1703466

Source DB:  PubMed          Journal:  Small GTPases        ISSN： 2154-1248


  87 in total

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3.  Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.

Authors:  Magdalena M Gorska; Qiaoling Liang; Zunayet Karim; Rafeul Alam
Journal:  J Immunol       Date:  2009-07-10       Impact factor: 5.422

4.  Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling.

Authors:  Cheryl J Wiens; Yufeng Tong; Muneer A Esmail; Edwin Oh; Jantje M Gerdes; Jihong Wang; Wolfram Tempel; Jerome B Rattner; Nicholas Katsanis; Hee-Won Park; Michel R Leroux
Journal:  J Biol Chem       Date:  2010-03-05       Impact factor: 5.157

5.  Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.

Authors:  Jian Qin; Yulian Lin; Ryan X Norman; Hyuk W Ko; Jonathan T Eggenschwiler
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-05       Impact factor: 11.205

6.  Phenotypic spectrum and prevalence of INPP5E mutations in Joubert syndrome and related disorders.

Authors:  Lorena Travaglini; Francesco Brancati; Jennifer Silhavy; Miriam Iannicelli; Elizabeth Nickerson; Nadia Elkhartoufi; Eric Scott; Emily Spencer; Stacey Gabriel; Sophie Thomas; Bruria Ben-Zeev; Enrico Bertini; Eugen Boltshauser; Malika Chaouch; Maria Roberta Cilio; Mirjam M de Jong; Hulya Kayserili; Gonul Ogur; Andrea Poretti; Sabrina Signorini; Graziella Uziel; Maha S Zaki; Colin Johnson; Tania Attié-Bitach; Joseph G Gleeson; Enza Maria Valente
Journal:  Eur J Hum Genet       Date:  2013-02-06       Impact factor: 4.246

7.  Mutations in human homologue of chicken talpid3 gene (KIAA0586) cause a hybrid ciliopathy with overlapping features of Jeune and Joubert syndromes.

Authors:  May Christine V Malicdan; Thierry Vilboux; Joshi Stephen; Dino Maglic; Luhe Mian; Daniel Konzman; Jennifer Guo; Deniz Yildirimli; Joy Bryant; Roxanne Fischer; Wadih M Zein; Joseph Snow; Meghana Vemulapalli; James C Mullikin; Camilo Toro; Benjamin D Solomon; John E Niederhuber; William A Gahl; Meral Gunay-Aygun
Journal:  J Med Genet       Date:  2015-09-18       Impact factor: 6.318

Review 8.  The immunological synapse: a focal point for endocytosis and exocytosis.

Authors:  Gillian M Griffiths; Andy Tsun; Jane C Stinchcombe
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9.  De Novo Occurrence of a Variant in ARL3 and Apparent Autosomal Dominant Transmission of Retinitis Pigmentosa.

Authors:  Samuel P Strom; Michael J Clark; Ariadna Martinez; Sarah Garcia; Amira A Abelazeem; Anna Matynia; Sachin Parikh; Lori S Sullivan; Sara J Bowne; Stephen P Daiger; Michael B Gorin
Journal:  PLoS One       Date:  2016-03-10       Impact factor: 3.240

10.  A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

Authors:  David K Breslow; Sascha Hoogendoorn; Adam R Kopp; David W Morgens; Brandon K Vu; Margaret C Kennedy; Kyuho Han; Amy Li; Gaelen T Hess; Michael C Bassik; James K Chen; Maxence V Nachury
Journal:  Nat Genet       Date:  2018-02-19       Impact factor: 38.330
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  4 in total

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Journal:  Elife       Date:  2022-09-05       Impact factor: 8.713

2.  Teasing out function from morphology: Similarities between primary cilia and immune synapses.

Authors:  Tiphaine Douanne; Jane C Stinchcombe; Gillian M Griffiths
Journal:  J Cell Biol       Date:  2021-05-06       Impact factor: 10.539

3.  Hnrnpul1 controls transcription, splicing, and modulates skeletal and limb development in vivo.

Authors:  Danielle L Blackwell; Sherri D Fraser; Oana Caluseriu; Claudia Vivori; Amanda V Tyndall; Ryan E Lamont; Jillian S Parboosingh; A Micheil Innes; François P Bernier; Sarah J Childs
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4.  Genetic compensation for cilia defects in cep290 mutants by upregulation of cilia-associated small GTPases.

Authors:  Magdalena Cardenas-Rodriguez; Christina Austin-Tse; Judith G M Bergboer; Elisa Molinari; Yuya Sugano; Ruxandra Bachmann-Gagescu; John A Sayer; Iain A Drummond
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  4 in total

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