Janet M Duchek1, Andrew J Aschenbrenner2,3, Anne M Fagan2,3, Tammie L S Benzinger3,4,5, John C Morris2,3, David A Balota1. 1. Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO63130, USA. 2. Department of Neurology, Washington University in St. Louis, St. Louis, MO63110, USA. 3. The Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, MO63110, USA. 4. Department of Radiology, Washington University in St. Louis, St. Louis, MO63110, USA. 5. Department of Neurological Surgery, Washington University in St. Louis, St. Louis, MO63110, USA.
Abstract
OBJECTIVES: The present study explored relationships among personality, Alzheimer's disease (AD) biomarkers, and dementia by addressing the following questions: (1) Does personality discriminate healthy aging and earliest detectable stage of AD? (2) Does personality predict conversion from healthy aging to early-stage AD? (3) Do AD biomarkers mediate any observed relationships between personality and dementia status/conversion? METHODS: Both self- and informant ratings of personality were obtained in a large well-characterized longitudinal sample of cognitively normal older adults (N = 436) and individuals with early-stage dementia (N = 74). Biomarkers included amyloid imaging, hippocampal volume, cerebral spinal fluid (CSF) Aβ42, and CSF tau. RESULTS: Higher neuroticism, lower conscientiousness, along with all four biomarkers strongly discriminated cognitively normal controls from early-stage AD individuals. The direct effects of neuroticism and conscientiousness were only mediated by hippocampal volume. Conscientiousness along with all biomarkers predicted conversion from healthy aging to early-stage AD; however, none of the biomarkers mediated the relationship between conscientiousness and conversion. Conscientiousness predicted conversion as strongly as the biomarkers, with the exception of hippocampal volume. CONCLUSIONS: Conscientiousness and to a lesser extent neuroticism serve as important independent behavioral markers for AD risk.
OBJECTIVES: The present study explored relationships among personality, Alzheimer's disease (AD) biomarkers, and dementia by addressing the following questions: (1) Does personality discriminate healthy aging and earliest detectable stage of AD? (2) Does personality predict conversion from healthy aging to early-stage AD? (3) Do AD biomarkers mediate any observed relationships between personality and dementia status/conversion? METHODS: Both self- and informant ratings of personality were obtained in a large well-characterized longitudinal sample of cognitively normal older adults (N = 436) and individuals with early-stage dementia (N = 74). Biomarkers included amyloid imaging, hippocampal volume, cerebral spinal fluid (CSF) Aβ42, and CSF tau. RESULTS: Higher neuroticism, lower conscientiousness, along with all four biomarkers strongly discriminated cognitively normal controls from early-stage AD individuals. The direct effects of neuroticism and conscientiousness were only mediated by hippocampal volume. Conscientiousness along with all biomarkers predicted conversion from healthy aging to early-stage AD; however, none of the biomarkers mediated the relationship between conscientiousness and conversion. Conscientiousness predicted conversion as strongly as the biomarkers, with the exception of hippocampal volume. CONCLUSIONS: Conscientiousness and to a lesser extent neuroticism serve as important independent behavioral markers for AD risk.
Authors: Robert S Wilson; Carlos F Mendes de Leon; Julia L Bienias; Denis A Evans; David A Bennett Journal: J Gerontol B Psychol Sci Soc Sci Date: 2004-05 Impact factor: 4.077
Authors: Chengjie Xiong; Catherine M Roe; Virginia Buckles; Anne Fagan; David Holtzman; David Balota; Janet Duchek; Martha Storandt; Mark Mintun; Elizabeth Grant; Abraham Z Snyder; Denise Head; Tammie L S Benzinger; Joseph Mettenburg; John Csernansky; John C Morris Journal: Arch Neurol Date: 2011-10
Authors: Stephanie A Schultz; Brian A Gordon; Shruti Mishra; Yi Su; John C Morris; Beau M Ances; Janet M Duchek; David A Balota; Tammie L S Benzinger Journal: Brain Imaging Behav Date: 2020-12 Impact factor: 3.978
Authors: Robert S Wilson; Kristin R Krueger; Steven E Arnold; Julie A Schneider; Jeremiah F Kelly; Lisa L Barnes; Yuxiao Tang; David A Bennett Journal: Arch Gen Psychiatry Date: 2007-02
Authors: Kirk I Erickson; Ruchika S Prakash; Michelle W Voss; Laura Chaddock; Liang Hu; Katherine S Morris; Siobhan M White; Thomas R Wójcicki; Edward McAuley; Arthur F Kramer Journal: Hippocampus Date: 2009-10 Impact factor: 3.899
Authors: Antonio Terracciano; Murat Bilgel; Damaris Aschwanden; Martina Luchetti; Yannick Stephan; Abhay R Moghekar; Dean F Wong; Luigi Ferrucci; Angelina R Sutin; Susan M Resnick Journal: Biol Psychiatry Date: 2021-09-03 Impact factor: 12.810
Authors: Damaris Aschwanden; Jason E Strickhouser; Martina Luchetti; Yannick Stephan; Angelina R Sutin; Antonio Terracciano Journal: Ageing Res Rev Date: 2021-02-06 Impact factor: 10.895
Authors: Angelina R Sutin; Yannick Stephan; Martina Luchetti; Jason E Strickhouser; Damaris Aschwanden; Antonio Terracciano Journal: Neuropsychol Dev Cogn B Aging Neuropsychol Cogn Date: 2021-01-19
Authors: Andrew J Aschenbrenner; Jennifer Petros; Eric McDade; Guoqiao Wang; David A Balota; Tammie Ls Benzinger; Carlos Cruchaga; Alison Goate; Chengjie Xiong; Richard Perrin; Anne M Fagan; Neill Graff-Radford; Bernardino Ghetti; Johannes Levin; Endy Weidinger; Peter Schofield; Susanne Gräber; Jae-Hong Lee; Jasmeer P Chhatwal; John C Morris; Randall Bateman; Jason Hassenstab Journal: Alzheimers Dement (Amst) Date: 2020-06-23