Antonio Terracciano1, Murat Bilgel2, Damaris Aschwanden3, Martina Luchetti4, Yannick Stephan5, Abhay R Moghekar6, Dean F Wong7, Luigi Ferrucci2, Angelina R Sutin4, Susan M Resnick2. 1. Department of Geriatrics, Florida State University College of Medicine, Tallahassee, Florida; Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland. Electronic address: antonio.terracciano@med.fsu.edu. 2. Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland. 3. Department of Geriatrics, Florida State University College of Medicine, Tallahassee, Florida. 4. Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee, Florida. 5. Euromov, University of Montpellier, Montpellier, France. 6. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland. 7. Department of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Abstract
BACKGROUND: Higher neuroticism and lower conscientiousness are risk factors for Alzheimer's disease and related dementias, but the underlying neuropathological correlates remain unclear. Our aim was to examine whether personality traits are associated with amyloid and tau neuropathology in a new sample and meta-analyses. METHODS: Participants from the BLSA (Baltimore Longitudinal Study of Aging) completed the Revised NEO Personality Inventory and underwent amyloid (11C-labeled Pittsburgh compound B) and tau (18F-flortaucipir) positron emission tomography. RESULTS: Among cognitively normal BLSA participants, neuroticism was associated with higher cortical amyloid burden (odds ratio 1.68, 95% CI 1.20-2.34), and conscientiousness was associated with lower cortical amyloid burden (odds ratio 0.61, 95% CI 0.44-0.86). These associations remained significant after accounting for age, sex, education, depressive symptoms, hippocampal volume, and APOE ε4. Similar associations were found with tau in the entorhinal cortex. Random-effects meta-analyses of 12 studies found that higher neuroticism (N = 3015, r = 0.07, p = .008) and lower conscientiousness (N = 2990, r = -0.11, p < .001) were associated with more amyloid deposition. Meta-analyses of 8 studies found that higher neuroticism (N = 2231, r = 0.15, p < .001) and lower conscientiousness (N = 2206, r = -0.14, p < .001) were associated with more tau pathology. The associations were moderated by cognitive status, with stronger effects in cognitively normal compared with heterogeneous samples, suggesting that the associations between personality and proteopathies are not phenomena that emerge with neuropsychiatric clinical symptoms. CONCLUSIONS: By aggregating results across samples, this study advances knowledge on the association between personality and neuropathology. Neuroticism and conscientiousness may contribute to resistance against amyloid and tau neuropathology.
BACKGROUND: Higher neuroticism and lower conscientiousness are risk factors for Alzheimer's disease and related dementias, but the underlying neuropathological correlates remain unclear. Our aim was to examine whether personality traits are associated with amyloid and tau neuropathology in a new sample and meta-analyses. METHODS: Participants from the BLSA (Baltimore Longitudinal Study of Aging) completed the Revised NEO Personality Inventory and underwent amyloid (11C-labeled Pittsburgh compound B) and tau (18F-flortaucipir) positron emission tomography. RESULTS: Among cognitively normal BLSA participants, neuroticism was associated with higher cortical amyloid burden (odds ratio 1.68, 95% CI 1.20-2.34), and conscientiousness was associated with lower cortical amyloid burden (odds ratio 0.61, 95% CI 0.44-0.86). These associations remained significant after accounting for age, sex, education, depressive symptoms, hippocampal volume, and APOE ε4. Similar associations were found with tau in the entorhinal cortex. Random-effects meta-analyses of 12 studies found that higher neuroticism (N = 3015, r = 0.07, p = .008) and lower conscientiousness (N = 2990, r = -0.11, p < .001) were associated with more amyloid deposition. Meta-analyses of 8 studies found that higher neuroticism (N = 2231, r = 0.15, p < .001) and lower conscientiousness (N = 2206, r = -0.14, p < .001) were associated with more tau pathology. The associations were moderated by cognitive status, with stronger effects in cognitively normal compared with heterogeneous samples, suggesting that the associations between personality and proteopathies are not phenomena that emerge with neuropsychiatric clinical symptoms. CONCLUSIONS: By aggregating results across samples, this study advances knowledge on the association between personality and neuropathology. Neuroticism and conscientiousness may contribute to resistance against amyloid and tau neuropathology.
Authors: Beth E Snitz; Lisa A Weissfeld; Ann D Cohen; Oscar L Lopez; Robert D Nebes; Howard J Aizenstein; Eric McDade; Julie C Price; Chester A Mathis; William E Klunk Journal: Am J Geriatr Psychiatry Date: 2015-02-11 Impact factor: 4.105
Authors: Hamid R Sohrabi; Kathryn Goozee; Michael Weinborn; Kaikai Shen; Belinda M Brown; Stephanie R Rainey-Smith; Olivier Salvado; Kevin Taddei; Romola S Bucks; Paul Maruff; Simon M Laws; Nat Lenzo; Manja Laws; Colin DeYoung; Craig Speelman; Christoph Laske; David Ames; Greg Savage; Ralph N Martins Journal: Brain Struct Funct Date: 2020-04-27 Impact factor: 3.270
Authors: Christopher A Lane; Josephine Barnes; Jennifer M Nicholas; Carole H Sudre; David M Cash; Ian B Malone; Thomas D Parker; Ashvini Keshavan; Sarah M Buchanan; Sarah E Keuss; Sarah-Naomi James; Kirsty Lu; Heidi Murray-Smith; Andrew Wong; Elizabeth Gordon; William Coath; Marc Modat; David Thomas; Marcus Richards; Nick C Fox; Jonathan M Schott Journal: JAMA Neurol Date: 2020-02-01 Impact factor: 18.302