INTRODUCTION: Congenital anomalies were the leading cause of infant mortality, responsible for 23 and 21% of deaths in Oklahoma and the USA, respectively, in 2016. We aimed to determine the prevalence by race/ethnicity and spatial distribution of congenital anomalies to identify geographic and racial/ethnic disparities, particularly among American Indian/Alaska Natives (AI/AN). METHODS: We evaluated the prevalence of anomalies by type and race/ethnicity among 648,074 live births in Oklahoma from 1997 to 2009. Prevalence proportion ratios (PPRs) and 95% confidence intervals (CIs) were calculated using Poisson regression. We used Moran's I and Getis-Ord Gi* to evaluate spatial clustering for neural tube defects, critical congenital heart defects (CCHDs), and oral clefts among births whose residence geocoded to the ZIP code or finer level. RESULTS: Overall prevalence of anomalies among live births was 3.9%. Non-Hispanic (NH) African American (PPR: 0.87, 95% CI: 0.83, 0.91), Asian/Pacific Islander (PPR: 0.70, 95% CI: 0.63, 0.78), and Hispanic (PPR: 0.87, 95% CI: 0.83, 0.91) children had a lower prevalence of anomalies compared to NH whites. The prevalence in NH AI/AN children was similar to NH whites (PPR: 1.01, 95% CI: 0.97, 1.05). However, differences in specific types of anomalies were observed by race/ethnicity. We observed no spatial autocorrelation for CCHD and oral clefts. Neural tube defects demonstrated spatial autocorrelation (p < .0001). Local hot spots varied by anomaly. DISCUSSION: The prevalence of anomalies by race/ethnicity and geography differed by race/ethnicity and region, though this varied by anomaly. Additional research is needed to identify behavioral or environmental factors to target for prevention.
INTRODUCTION:Congenital anomalies were the leading cause of infantmortality, responsible for 23 and 21% of deaths in Oklahoma and the USA, respectively, in 2016. We aimed to determine the prevalence by race/ethnicity and spatial distribution of congenital anomalies to identify geographic and racial/ethnic disparities, particularly among American Indian/Alaska Natives (AI/AN). METHODS: We evaluated the prevalence of anomalies by type and race/ethnicity among 648,074 live births in Oklahoma from 1997 to 2009. Prevalence proportion ratios (PPRs) and 95% confidence intervals (CIs) were calculated using Poisson regression. We used Moran's I and Getis-Ord Gi* to evaluate spatial clustering for neural tube defects, critical congenital heart defects (CCHDs), and oral clefts among births whose residence geocoded to the ZIP code or finer level. RESULTS: Overall prevalence of anomalies among live births was 3.9%. Non-Hispanic (NH) African American (PPR: 0.87, 95% CI: 0.83, 0.91), Asian/Pacific Islander (PPR: 0.70, 95% CI: 0.63, 0.78), and Hispanic (PPR: 0.87, 95% CI: 0.83, 0.91) children had a lower prevalence of anomalies compared to NH whites. The prevalence in NH AI/AN children was similar to NH whites (PPR: 1.01, 95% CI: 0.97, 1.05). However, differences in specific types of anomalies were observed by race/ethnicity. We observed no spatial autocorrelation for CCHD and oral clefts. Neural tube defects demonstrated spatial autocorrelation (p < .0001). Local hot spots varied by anomaly. DISCUSSION: The prevalence of anomalies by race/ethnicity and geography differed by race/ethnicity and region, though this varied by anomaly. Additional research is needed to identify behavioral or environmental factors to target for prevention.
Authors: Christine E Cronk; Ronald Gangnon; Stacy Cossette; Jane A McElroy; Andrew N Pelech Journal: Birth Defects Res A Clin Mol Teratol Date: 2011-05-31
Authors: Mimi T Le; Charlie J Shumate; Adrienne T Hoyt; Anna V Wilkinson; Mark A Canfield Journal: Birth Defects Res Date: 2019-07-01 Impact factor: 2.344
Authors: Jean Paul Tanner; Jason L Salemi; Amy L Stuart; Haofei Yu; Melissa M Jordan; Chris DuClos; Philip Cavicchia; Jane A Correia; Sharon M Watkins; Russell S Kirby Journal: Environ Res Date: 2015-07-18 Impact factor: 6.498
Authors: Philip J Lupo; Jeremy M Schraw; Tania A Desrosiers; Wendy N Nembhard; Peter H Langlois; Mark A Canfield; Glenn Copeland; Robert E Meyer; Austin L Brown; Tiffany M Chambers; Pagna Sok; Heather E Danysh; Susan E Carozza; Saumya D Sisoudiya; Susan G Hilsenbeck; Amanda E Janitz; Matthew E Oster; Angela E Scheuerle; Joshua D Schiffman; Chunqiao Luo; Amir Mian; Beth A Mueller; Chad D Huff; Sonja A Rasmussen; Michael E Scheurer; Sharon E Plon Journal: JAMA Oncol Date: 2019-08-01 Impact factor: 31.777