| Literature DB >> 31813069 |
Padacherri Vethil Jishnu1, Pradyumna Jayaram1, Vaibhav Shukla1, Vinay Koshy Varghese1, Deeksha Pandey2, Krishna Sharan3, Sanjiban Chakrabarty1, Kapaettu Satyamoorthy1, Shama Prasada Kabekkodu4.
Abstract
Deregulated miR-379/miR-656 cluster expression is considered as important for carcinogenesis and can be used as a potential prognostic marker. Hence, the meta-analysis was conducted to test the utility of miR-379/miR-656 cluster as a prognostic marker in various cancers. A literature search was performed using Web of Science, PubMed and Cochrane Library to obtain relevant studies and were subjected to various subgroup and bioinformatics analyses. Selected twenty-three studies contained 13 cancer types comprising of 3294 patients from 7 nations. Univariate and multivariate data showed an association of high expression of miRNAs with the poor prognosis of cancer patients (p < 0.001). The subgroup analysis showed that lung cancer, breast cancer and papillary renal cell carcinoma (p < 0.001) have a negative association with the survival of patients. Our study is the first meta-analysis showing the association of miR-379/miR-656 cluster expression and overall survival, suggesting its potential as a prognostic indicator in multiple cancers.Entities:
Keywords: Cancer; Meta-analysis; Prognostic marker; microRNA cluster; microRNA drug target
Year: 2019 PMID： 31813069 DOI： 10.1007/s10585-019-10013-2
Source DB: PubMed Journal: Clin Exp Metastasis ISSN： 0262-0898 Impact factor: 5.150