| Literature DB >> 31806905 |
David Furman1,2,3,4, Judith Campisi5,6, Eric Verdin5, Pedro Carrera-Bastos7, Sasha Targ8,9, Claudio Franceschi10,11, Luigi Ferrucci12, Derek W Gilroy13, Alessio Fasano14, Gary W Miller15, Andrew H Miller16, Alberto Mantovani17,18,19, Cornelia M Weyand20, Nir Barzilai21, Jorg J Goronzy22, Thomas A Rando22,23,24, Rita B Effros25, Alejandro Lucia26,27, Nicole Kleinstreuer28,29, George M Slavich30.
Abstract
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.Entities:
Mesh：
Year: 2019 PMID： 31806905 PMCID： PMC7147972 DOI： 10.1038/s41591-019-0675-0
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440