Literature DB >> 31806689

LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA.

Audrey Belot1, Ophélie Gourbeyre1, Alexis Fay1, Anais Palin1, Céline Besson-Fournier1, Chloé Latour1, Corey R Hopkins2, George F Tidmarsh3, Hélène Coppin1, Marie-Paule Roth1, Matthew R Ritter3, Charles C Hong4, Delphine Meynard5.   

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Year:  2019        PMID： 31806689      PMCID： PMC7395282          DOI： 10.3324/haematol.2019.236133

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


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  15 in total

1.  In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors.

Authors:  Jijun Hao; Joshua N Ho; Jana A Lewis; Kaleh A Karim; R Nathan Daniels; Patrick R Gentry; Corey R Hopkins; Craig W Lindsley; Charles C Hong
Journal:  ACS Chem Biol       Date:  2010-02-19       Impact factor: 5.100

2.  Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels.

Authors:  Suzana Kovac; Preethne Böser; Yifang Cui; Dunja Ferring-Appel; Daniela Casarrubea; Lili Huang; Emma Fung; Andreas Popp; Bernhard K Mueller; Matthias W Hentze
Journal:  Haematologica       Date:  2016-03-04       Impact factor: 9.941

3.  Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis.

Authors:  Philipp-Sebastian Koch; Victor Olsavszky; Friederike Ulbrich; Carsten Sticht; Alexandra Demory; Thomas Leibing; Thomas Henzler; Mathias Meyer; Johanna Zierow; Sven Schneider; Katja Breitkopf-Heinlein; Haristi Gaitantzi; Bradley Spencer-Dene; Bernd Arnold; Kay Klapproth; Kai Schledzewski; Sergij Goerdt; Cyrill Géraud
Journal:  Blood       Date:  2016-11-30       Impact factor: 22.113

4.  Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice.

Authors:  Andrea U Steinbicker; Thomas B Bartnikas; Lisa K Lohmeyer; Patricio Leyton; Claire Mayeur; Sonya M Kao; Alexandra E Pappas; Randall T Peterson; Donald B Bloch; Paul B Yu; Mark D Fleming; Kenneth D Bloch
Journal:  Blood       Date:  2011-08-12       Impact factor: 22.113

5.  Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness.

Authors:  Jaroslav Truksa; Pauline Lee; Ernest Beutler
Journal:  Blood       Date:  2008-11-07       Impact factor: 22.113

6.  Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.

Authors:  Paul B Yu; Charles C Hong; Chetana Sachidanandan; Jodie L Babitt; Donna Y Deng; Stefan A Hoyng; Herbert Y Lin; Kenneth D Bloch; Randall T Peterson
Journal:  Nat Chem Biol       Date:  2007-11-18       Impact factor: 15.040

7.  Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA).

Authors:  Karin E Finberg; Matthew M Heeney; Dean R Campagna; Yeşim Aydinok; Howard A Pearson; Kip R Hartman; Mary M Mayo; Stewart M Samuel; John J Strouse; Kyriacos Markianos; Nancy C Andrews; Mark D Fleming
Journal:  Nat Genet       Date:  2008-04-13       Impact factor: 38.330

8.  BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism.

Authors:  Claire Mayeur; Patricio A Leyton; Starsha A Kolodziej; Binglan Yu; Kenneth D Bloch
Journal:  Blood       Date:  2014-07-29       Impact factor: 22.113

9.  Lack of the bone morphogenetic protein BMP6 induces massive iron overload.

Authors:  Delphine Meynard; Léon Kautz; Valérie Darnaud; François Canonne-Hergaux; Hélène Coppin; Marie-Paule Roth
Journal:  Nat Genet       Date:  2009-03-01       Impact factor: 38.330

Review 10.  The role of TMPRSS6/matriptase-2 in iron regulation and anemia.

Authors:  Chia-Yu Wang; Delphine Meynard; Herbert Y Lin
Journal:  Front Pharmacol       Date:  2014-05-19       Impact factor: 5.810
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  7 in total

1.  Discovery of Novel Pyrazolopyrimidines as Potent, Selective, and Orally Bioavailable Inhibitors of ALK2.

Authors:  Minh H Nguyen; Onur Atasoylu; Liangxing Wu; Kanishk Kapilashrami; Michelle Pusey; Karen Gallagher; Cheng-Tsung Lai; Peng Zhao; Joseph Barbosa; Kai Liu; Chunhong He; Colin Zhang; Evan D Styduhar; Michael R Witten; Yaoyu Chen; Luping Lin; Yan-Ou Yang; Maryanne Covington; Sharon Diamond; Swamy Yeleswaram; Wenqing Yao
Journal:  ACS Med Chem Lett       Date:  2022-06-22       Impact factor: 4.632

Review 2.  Bone morphogenic proteins in iron homeostasis.

Authors:  Xia Xiao; Víctor M Alfaro-Magallanes; Jodie L Babitt
Journal:  Bone       Date:  2020-06-23       Impact factor: 4.398

Review 3.  Physiological and pathophysiological mechanisms of hepcidin regulation: clinical implications for iron disorders.

Authors:  Yang Xu; Víctor M Alfaro-Magallanes; Jodie L Babitt
Journal:  Br J Haematol       Date:  2020-12-14       Impact factor: 8.615

Review 4.  Physiology and Inflammation Driven Pathophysiology of Iron Homeostasis-Mechanistic Insights into Anemia of Inflammation and Its Treatment.

Authors:  Lukas Lanser; Dietmar Fuchs; Katharina Kurz; Günter Weiss
Journal:  Nutrients       Date:  2021-10-22       Impact factor: 5.717

5.  Double trouble: A case of fraternal twins with iron-refractory iron-deficiency anemia.

Authors:  Jacques A J Malherbe; Catherine H Cole
Journal:  Clin Case Rep       Date:  2022-10-13

6.  Iron distribution in different tissues of homozygous Mask (msk/msk) mice and the effects of oral iron treatments.

Authors:  Michela Asperti; Elisa Brilli; Andrea Denardo; Magdalena Gryzik; Francesca Pagani; Fabiana Busti; Germano Tarantino; Paolo Arosio; Domenico Girelli; Maura Poli
Journal:  Am J Hematol       Date:  2021-08-14       Impact factor: 13.265

7.  Pharmacological Targeting of BMP6-SMAD Mediated Hepcidin Expression Does Not Improve the Outcome of Systemic Infections With Intra-Or Extracellular Gram-Negative Bacteria in Mice.

Authors:  Alexander Hoffmann; Lara Valente de Souza; Markus Seifert; Laura von Raffay; David Haschka; Philipp Grubwieser; Manuel Grander; Anna-Maria Mitterstiller; Manfred Nairz; Maura Poli; Günter Weiss
Journal:  Front Cell Infect Microbiol       Date:  2021-07-23       Impact factor: 5.293
  7 in total

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