Literature DB >> 26944476

Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels.

Suzana Kovac1, Preethne Böser2, Yifang Cui2, Dunja Ferring-Appel1, Daniela Casarrubea1, Lili Huang3, Emma Fung3, Andreas Popp4, Bernhard K Mueller4, Matthias W Hentze5.   

Abstract

Entities:  

Keywords:  anemia; erythroblastic island; erythropoiesis; myelodysplastic syndromes; prognosis

Mesh：

Substances：

Year:  2016        PMID： 26944476      PMCID： PMC5004359          DOI： 10.3324/haematol.2015.140772

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


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  20 in total

1.  Soluble repulsive guidance molecule c/hemojuvelin is a broad spectrum bone morphogenetic protein (BMP) antagonist and inhibits both BMP2- and BMP6-mediated signaling and gene expression.

Authors:  Mahta Nili; Ujwal Shinde; Peter Rotwein
Journal:  J Biol Chem       Date:  2010-06-08       Impact factor: 5.157

2.  Anemia: not just an innocent bystander?

Authors:  Allen R Nissenson; Lawrence T Goodnough; Robert W Dubois
Journal:  Arch Intern Med       Date:  2003-06-23

3.  Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats.

Authors:  Igor Theurl; Andrea Schroll; Thomas Sonnweber; Manfred Nairz; Milan Theurl; Wolfgang Willenbacher; Kathrin Eller; Dominik Wolf; Markus Seifert; Chia Chi Sun; Jodie L Babitt; Charles C Hong; Tracey Menhall; Patrick Gearing; Herbert Y Lin; Guenter Weiss
Journal:  Blood       Date:  2011-07-05       Impact factor: 22.113

4.  Anemia as an independent prognostic factor for survival in patients with cancer: a systemic, quantitative review.

Authors:  J J Caro; M Salas; A Ward; G Goss
Journal:  Cancer       Date:  2001-06-15       Impact factor: 6.860

5.  Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.

Authors:  Jodie L Babitt; Franklin W Huang; Diedra M Wrighting; Yin Xia; Yisrael Sidis; Tarek A Samad; Jason A Campagna; Raymond T Chung; Alan L Schneyer; Clifford J Woolf; Nancy C Andrews; Herbert Y Lin
Journal:  Nat Genet       Date:  2006-04-09       Impact factor: 38.330

6.  Inflammation and resistance to treatment with recombinant human erythropoietin.

Authors:  Lucia Del Vecchio; Pietro Pozzoni; Simeone Andrulli; Francesco Locatelli
Journal:  J Ren Nutr       Date:  2005-01       Impact factor: 3.655

7.  The anemia of inflammation/malignancy: mechanisms and management.

Authors:  John W Adamson
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2008

8.  Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia.

Authors:  Barbra J Sasu; Keegan S Cooke; Tara L Arvedson; Cherylene Plewa; Aaron R Ellison; Jackie Sheng; Aaron Winters; Todd Juan; Hongyan Li; C Glenn Begley; Graham Molineux
Journal:  Blood       Date:  2010-01-06       Impact factor: 22.113

9.  A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates.

Authors:  Keegan S Cooke; Beth Hinkle; Hossein Salimi-Moosavi; Ian Foltz; Chadwick King; Palaniswami Rathanaswami; Aaron Winters; Shirley Steavenson; C Glenn Begley; Graham Molineux; Barbra J Sasu
Journal:  Blood       Date:  2013-08-14       Impact factor: 22.113

10.  The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin.

Authors:  Laura Silvestri; Alessia Pagani; Antonella Nai; Ivana De Domenico; Jerry Kaplan; Clara Camaschella
Journal:  Cell Metab       Date:  2008-10-30       Impact factor: 27.287
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  17 in total

1.  LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA.

Authors:  Audrey Belot; Ophélie Gourbeyre; Alexis Fay; Anais Palin; Céline Besson-Fournier; Chloé Latour; Corey R Hopkins; George F Tidmarsh; Hélène Coppin; Marie-Paule Roth; Matthew R Ritter; Charles C Hong; Delphine Meynard
Journal:  Haematologica       Date:  2019-12-05       Impact factor: 9.941

2.  Effects of Anti-repulsive Guidance Molecule C (RGMc/Hemojuvelin) Antibody on Hepcidin and Iron in Mouse Liver and Tumor Xenografts.

Authors:  S V Torti; E Lemler; B K Mueller; A Popp; F M Torti
Journal:  Clin Exp Pharmacol       Date:  2016-11-17

Review 3.  Inherited microcytic anemias.

Authors:  Maria Domenica Cappellini; Roberta Russo; Immacolata Andolfo; Achille Iolascon
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2020-12-04

Review 4.  Bone morphogenic proteins in iron homeostasis.

Authors:  Xia Xiao; Víctor M Alfaro-Magallanes; Jodie L Babitt
Journal:  Bone       Date:  2020-06-23       Impact factor: 4.398

5.  Coordination of iron homeostasis by bone morphogenetic proteins: Current understanding and unanswered questions.

Authors:  Allison L Fisher; Jodie L Babitt
Journal:  Dev Dyn       Date:  2021-05-25       Impact factor: 3.780

Review 6.  The Role of Iron in Benign and Malignant Hematopoiesis.

Authors:  Sayantani Sinha; Joana Pereira-Reis; Amaliris Guerra; Stefano Rivella; Delfim Duarte
Journal:  Antioxid Redox Signal       Date:  2021-01-07       Impact factor: 7.468

Review 7.  Physiological and pathophysiological mechanisms of hepcidin regulation: clinical implications for iron disorders.

Authors:  Yang Xu; Víctor M Alfaro-Magallanes; Jodie L Babitt
Journal:  Br J Haematol       Date:  2020-12-14       Impact factor: 8.615

8.  Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.

Authors:  Stanzin Angmo; Neha Tripathi; Sheenu Abbat; Shailesh Sharma; Shelley Sardul Singh; Avishek Halder; Kamalendra Yadav; Geeta Shukla; Rajat Sandhir; Vikas Rishi; Prasad V Bharatam; Hariom Yadav; Nitin Kumar Singhal
Journal:  Sci Rep       Date:  2017-01-05       Impact factor: 4.379

9.  Iron distribution in different tissues of homozygous Mask (msk/msk) mice and the effects of oral iron treatments.

Authors:  Michela Asperti; Elisa Brilli; Andrea Denardo; Magdalena Gryzik; Francesca Pagani; Fabiana Busti; Germano Tarantino; Paolo Arosio; Domenico Girelli; Maura Poli
Journal:  Am J Hematol       Date:  2021-08-14       Impact factor: 13.265

Review 10.  Pharmacological Targeting of the Hepcidin/Ferroportin Axis.

Authors:  Giada Sebastiani; Nicole Wilkinson; Kostas Pantopoulos
Journal:  Front Pharmacol       Date:  2016-06-21       Impact factor: 5.810
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