Literature DB >> 24601655

Netamines H-N, tricyclic alkaloids from the marine sponge Biemna laboutei and their antimalarial activity.

Emmanuelle Gros1, Ali Al-Mourabit, Marie-Thérèse Martin, Jonathan Sorres, Jean Vacelet, Michel Frederich, Maurice Aknin, Yoel Kashman, Anne Gauvin-Bialecki.   

Abstract

Chemical examination of the CH2Cl2-MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H-N (1-7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 μM.

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Year:  2014        PMID： 24601655     DOI： 10.1021/np4009283

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

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5.  Metabolites from Marine Sponges and Their Potential to Treat Malarial Protozoan Parasites Infection: A Systematic Review.

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Review 6.  Cytotoxic Alkaloids Derived from Marine Sponges: A Comprehensive Review.

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  10 in total

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