E Mirallié1, F Borel1, C Tresallet2, A Hamy3, M Mathonnet4, J C Lifante5, L Brunaud6, F Menégaux2, J B Hardouin7,8, C Blanchard1,9, Catherine Ansquer, Emmanuelle Mourrain-Langlois, Anne Sophie Delemazure, Bastien Perrot, Mylène Longhi, Claire Nominé, Florent Espitalier, Delphine Drui, Cécile Caillard, Nelly Renaud-Moreau, Oliver Marret, Stéphanie Mucci, Niki Christou. 1. Chirurgie Cancérologique, Digestive et Endocrinienne, Hôtel Dieu, CHU Nantes, Place Alexis Ricordeau, Nantes Cedex 1, France. 2. Chirurgie Générale, Viscérale et Endocrinienne, Hôpital Pitié-Salpêtrière, AP-HP, Sorbonne Universités Pierre et Marie Curie (Paris 6), Paris, France. 3. CHU Angers, Chirurgie Digestive et Endocrinienne, Angers Cedex 09, France. 4. Chirurgie Digestive, Générale et Endocrinienne, CHU de Limoges - Hôpital Dupuytren, Limoges Cedex, France. 5. Chirurgie Générale, Endocrinienne, Digestive et Thoracique, Centre Hospitalier Lyon-Sud, Pierre Bénite Cedex, France. 6. Service de Chirurgie Digestive, Hépato-Biliaire, et Endocrinienne, CHU Nancy - Hôpital de Brabois, Nancy, France. 7. UMR INSERM 1246-SPHERE, Université de Nantes, Université de Tours-Institut de Recherche en santé 2, Nantes, France. 8. Plateforme de Méthodologie et de Biostatistique - DRCi - CHU de Nantes, Nantes, France. 9. Institut du Thorax, INSERM, CNRS, UNIV Nantes, Nantes, France.
Abstract
OBJECTIVE: This study is to determine the impact of complications after total thyroidectomy on health-related quality of life (HR-QoL) and to identify significant predictive factors of HR-QoL changes. HR-QoL is usually impaired in patients with thyroid diseases compared to the general population. Thyroidectomy is largely performed in the case of benign thyroid benign and can be associated with long-term complications (vocal cord palsy, hypoparathyroidism). DESIGN: The prospective ThyrQoL multicenter trial (NCT02167529) included 800 patients who underwent total thyroidectomy for benign or malignant non-extensive disease in seven French referral hospitals between 2014 and 2016. METHODS: HR-QoL was assessed using the MOS 36-item short form health survey (SF-36) self-questionnaire with a 6-month follow-up. RESULTS: We observed a significant improvement of HR-QoL 6 months after surgery (P < 0.0001). Postoperative complications were associated with a non-significant impairment of HR-QoL. In multivariable analysis, Graves' disease was associated with a significant improvement of HR-QoL (OR = 2.39 [1.49; 3.84]) and thyroid malignant disease with an impairment of HR-QoL (OR = 1.44 [0.99; 2.08]) after thyroidectomy. CONCLUSION: We observed a significant improvement of HR-QoL 6 months after total thyroid surgery for benign thyroid disease.
OBJECTIVE: This study is to determine the impact of complications after total thyroidectomy on health-related quality of life (HR-QoL) and to identify significant predictive factors of HR-QoL changes. HR-QoL is usually impaired in patients with thyroid diseases compared to the general population. Thyroidectomy is largely performed in the case of benign thyroid benign and can be associated with long-term complications (vocal cord palsy, hypoparathyroidism). DESIGN: The prospective ThyrQoL multicenter trial (NCT02167529) included 800 patients who underwent total thyroidectomy for benign or malignant non-extensive disease in seven French referral hospitals between 2014 and 2016. METHODS: HR-QoL was assessed using the MOS 36-item short form health survey (SF-36) self-questionnaire with a 6-month follow-up. RESULTS: We observed a significant improvement of HR-QoL 6 months after surgery (P < 0.0001). Postoperative complications were associated with a non-significant impairment of HR-QoL. In multivariable analysis, Graves' disease was associated with a significant improvement of HR-QoL (OR = 2.39 [1.49; 3.84]) and thyroid malignant disease with an impairment of HR-QoL (OR = 1.44 [0.99; 2.08]) after thyroidectomy. CONCLUSION: We observed a significant improvement of HR-QoL 6 months after total thyroid surgery for benign thyroid disease.
Authors: Natalia Chaves; M Juanita Rodriguez; Jordan M Broekhuis; Hao Wei Chen; Paul A Bain; Benjamin C James Journal: World J Surg Date: 2022-01-24 Impact factor: 3.352
Authors: Elizabeth J de Koster; Olga Husson; Eveline W C M van Dam; G Sophie Mijnhout; Romana T Netea-Maier; Wim J G Oyen; Marieke Snel; Lioe-Fee de Geus-Oei; Dennis Vriens Journal: Endocr Connect Date: 2022-07-19 Impact factor: 3.221