Literature DB >> 3180218

Converting a eukaryotic transcriptional inhibitor into an activator.

J Ma1, M Ptashne.   

Abstract

GAL80, an inhibitor of the yeast transcriptional activator GAL4, is converted into an activator by inserting an acidic activating sequence into it. This hybrid activator does not bind to DNA directly, but is brought to DNA by interacting with a derivative of GAL4 that interacts with both DNA and GAL80.

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Year:  1988        PMID： 3180218     DOI： 10.1016/0092-8674(88)90030-x

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  37 in total

Review 1.  Demystified.... Transcription.

Authors:  W M Macfarlane
Journal:  Mol Pathol       Date:  2000-02

2.  Using the two-hybrid screen in the classroom laboratory.

Authors:  Daniel P Odom; Martha J Grossel
Journal:  Cell Biol Educ       Date:  2002

3.  A new method for the selection of protein interactions in mammalian cells.

Authors:  E Rojo-Niersbach; D Morley; S Heck; N Lehming
Journal:  Biochem J       Date:  2000-06-15       Impact factor: 3.857

4.  The isolation of transcription factors from lambda gt11 cDNA expression libraries: human steroid 5 alpha-reductase 1 has sequence-specific DNA binding activity.

Authors:  K Gaston; M Fried
Journal:  Nucleic Acids Res       Date:  1992-12-11       Impact factor: 16.971

Review 5.  Transcriptional activators and activation mechanisms.

Authors:  Jun Ma
Journal:  Protein Cell       Date:  2011-12-17       Impact factor: 14.870

Review 6.  Diversity in genetic in vivo methods for protein-protein interaction studies: from the yeast two-hybrid system to the mammalian split-luciferase system.

Authors:  Bram Stynen; Hélène Tournu; Jan Tavernier; Patrick Van Dijck
Journal:  Microbiol Mol Biol Rev       Date:  2012-06       Impact factor: 11.056

7.  The acid domain located at the C-terminus of the Su(Hw) protein represses transcription in the yeast two-hybrid system.

Authors:  A M Mazur; P G Georgiev; A K Golovnin
Journal:  Dokl Biochem Biophys       Date:  2005 Jan-Feb       Impact factor: 0.788

8.  Analysis of interaction between proteins containing the BTB domain in the yeast two-hybrid system.

Authors:  A M Mazur; P G Georgiev; A K Golovnin
Journal:  Dokl Biochem Biophys       Date:  2005 Jan-Feb       Impact factor: 0.788

9.  Detecting interactions between eukaryotic proteins in bacteria.

Authors:  J Ma
Journal:  Gene Expr       Date:  1992

10.  Replication initiation at a distance: determination of the cis- and trans-acting elements of replication origin alpha of plasmid R6K.

Authors:  Mukesh Saxena; Mayuresh Abhyankar; Deepak Bastia
Journal:  J Biol Chem       Date:  2009-12-15       Impact factor: 5.157
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