Renata Miranda Rodrigues1, Vagner Gonçalves Bernardo2, Sabrina Daniela Da Silva3, Danielle Resende Camisasca4, Paulo Antônio de Silvestre Faria5, Fernando Luiz Dias6, Luís Felipe Ribeiro Pinto7, Rodolpho Mattos Albano2, Anke Bergmann7, Simone de Queiroz Chaves Lourenço1. 1. Universidade Federal Fluminense, Programa de Graduação em Odontologia, Niterói, Rio de Janeiro, Brasil. 2. Universidade Estadual do Rio de Janeiro (UERJ), Departamento de Bioquímica, Rio de Janeiro, Rio de Janeiro, Brasil. 3. Segal Cancer Centre, Department of Otolaryngology, Head and Neck Surgery; Sir Mortimer B. Davis-Jewish General Hospital, Lady Davis Institute for Medical Research, Montréal, Canada. 4. Universidade Federal do Espírito Santo, Departamento de Patologia Oral, Vitória, Espírito Santo, Brasil. 5. Instituto Nacional de Câncer (INCA), Divisão de Patologia, Rio de Janeiro, Rio de Janeiro, Brasil. 6. Instituto Nacional de Câncer (INCA), Departamento de Cirurgia de Cabeça e Pescoço, Rio de Janeiro, Rio de Janeiro, Brasil. 7. Instituto Nacional de Câncer (INCA), Centro de Pesquisas, Programa de Carcinogênese Molecular.
Abstract
other: Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. OBJECTIVE: The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC). METHODOLOGY: In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005). RESULTS: Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS. CONCLUSION: Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC.
other: Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. OBJECTIVE: The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC). METHODOLOGY: In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005). RESULTS: Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS. CONCLUSION: Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC.