Amol Ramchandra Gadbail1, Sachin C Sarode2, Minal S Chaudhary3, Shailesh M Gondivkar4, Satyajit Ashok Tekade5, Monal Yuwanati6, Shankargouda Patil7. 1. Indira Gandhi Government Medical College and Hospital, Department of Dentistry, Nagpur, Maharashtra, India. 2. Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Department of Oral Pathology and Microbiology, Pimpri, India. 3. Datta Meghe Institute of Medical Sciences, Sharad Pawar Dental College & Hospital, Department of Oral Pathology and Microbiology, Sawangi (M), Wardha, Maharashtra, India. 4. Government Dental College & Hospital, Department of Oral Medicine and Radiology, Nagpur, Maharashtra, India. 5. Modern Dental College & Research Centre, Department of Oral Pathology and Microbiology, Gandhi Nagar, Indore, Madhya Pradesh 453112, India. 6. People's University, People's College of Dental Science & Research Centre, Department of Oral Pathology and Microbiology, Bhopal, Madhya Pradesh, India. 7. Jazan University, College of Dentistry, Division of Oral Pathology, Department of Maxillofacial Surgery and Diagnostic Sciences, Jazan, Saudi Arabia.
Abstract
OBJECTIVE: To investigate the Ki 67 expression and its correlation with clinicopathological features and 3 years as well as 5 years survival rate in oral squamous cell carcinoma (OSCC). METHODOLOGY: Total 217cases of OSCC primarily treated with surgery with or without radiation were included. All patients were followed up for 3 years and 150 were followed up of 5 years for disease free survival. The immunohistochemistry was carried out on neutral buffered formalin fixed paraffin embedded tissue to evaluate the expression of Ki67. RESULTS: The Ki67 labeling index (LI) was significantly higher with respect to adverse clinicopathological parameters such as histopathological grading (p<0.001), clinical TNM staging (p<0.001) and nodal metastasis (p<0.001). The OSCC patients survived for less than 3 and 5 years were showed significantly higher Ki67 LI as compared to diseases free survived more than 3 and 5 years(p<0.001). The three years survival rate of OSCC patient significantly higher with low Ki67 LI (≤45) 96.2%, followed by moderate Ki67 LI (46 to 60) 60.7% and high Ki67 LI (≥61) 37.7% (p<0.001). The five years survival rate of OSCC patient statistically significantly higher with low Ki67 LI (≤45)93.3%, followed by moderate Ki67 LI (46 to 60) 46.8% and Ki67 LI (≥61) 23.3% (p<0.001). CONCLUSION: The measurement of cell proliferative activity by using Ki67 antigen expression in individual OSCC might provide unique, predictive information on clinical outcome, prognosis and deciding treatment modalities in OSCC.
OBJECTIVE: To investigate the Ki 67 expression and its correlation with clinicopathological features and 3 years as well as 5 years survival rate in oral squamous cell carcinoma (OSCC). METHODOLOGY: Total 217cases of OSCC primarily treated with surgery with or without radiation were included. All patients were followed up for 3 years and 150 were followed up of 5 years for disease free survival. The immunohistochemistry was carried out on neutral buffered formalin fixed paraffin embedded tissue to evaluate the expression of Ki67. RESULTS: The Ki67 labeling index (LI) was significantly higher with respect to adverse clinicopathological parameters such as histopathological grading (p<0.001), clinical TNM staging (p<0.001) and nodal metastasis (p<0.001). The OSCC patients survived for less than 3 and 5 years were showed significantly higher Ki67 LI as compared to diseases free survived more than 3 and 5 years(p<0.001). The three years survival rate of OSCC patient significantly higher with low Ki67 LI (≤45) 96.2%, followed by moderate Ki67 LI (46 to 60) 60.7% and high Ki67 LI (≥61) 37.7% (p<0.001). The five years survival rate of OSCC patient statistically significantly higher with low Ki67 LI (≤45)93.3%, followed by moderate Ki67 LI (46 to 60) 46.8% and Ki67 LI (≥61) 23.3% (p<0.001). CONCLUSION: The measurement of cell proliferative activity by using Ki67 antigen expression in individual OSCC might provide unique, predictive information on clinical outcome, prognosis and deciding treatment modalities in OSCC.
Authors: M Matsumoto; K Komiyama; M Okaue; Y Shimoyama; K Iwakami; S Namaki; H Tanaka; I Moro; H Sato Journal: J Oral Sci Date: 1999-06 Impact factor: 1.556
Authors: Amol R Gadbail; Minal S Chaudhary; Sachin C Sarode; Shailesh M Gondivkar; Lalita Belekar; Mugdha P Mankar-Gadbail; Ravi Dande; Satyajit A Tekade; Monal B Yuwanati; Shankargouda Patil Journal: J Investig Clin Dent Date: 2019-07-19
Authors: Satiro Watanabe; Rogério Watanabe; Angélica F Oton-Leite; Rita de C G Alencar; José C Oliveira; Cláudio R Leles; Aline C Batista; Elismauro F Mendonça Journal: J Oral Sci Date: 2010-09 Impact factor: 1.556