Pei-Kang Liu1,2,3,4, Yo-Chen Chang1,4, Ming-Hong Tai3,5,6, Rong-Kung Tsai7,8, Inn-Wen Chong4,9,10, Kwou-Yeung Wu1,4, Wen-Chuan Wu1,4, Chung-Yao Hsu4,11,12, Ming-Ju Tsai4,9,10,12,13. 1. Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. 2. Department of Ophthalmology, Yuan's General Hospital, Kaohsiung, Taiwan. 3. Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan. 4. School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. 5. Center for Neuroscience, National Sun Yat-Sen University, Kaohsiung, Taiwan. 6. Graduate Program in Marine Biotechnology, National Sun Yat-Sen University, Kaohsiung, Taiwan. 7. Institute of Eye Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. 8. Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. 9. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. 10. Department of Respiratory Care, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. 11. Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. 12. Sleep Disorders Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; and. 13. Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Abstract
PURPOSE: To identify the association between sleep apnea (SA) and central serous chorioretinopathy (CSC). METHODS: In this nationwide population-based study using the Taiwan National Health Insurance Database, we enrolled adult patients with a diagnosis of SA and matched each patient to 30 age- and gender-matched control subjects without any SA diagnosis. Using Poisson regression analyses, the incidence rate of CSC was compared between SA patients and control subjects. RESULTS: A total of 10,753 SA patients and 322,590 control subjects were identified. After adjusting for age, gender, residency, income level, and comorbidities, the incidence rate of CSC was significantly higher in SA patients than in the control subjects (adjusted incident rate ratio for probable SA: 1.2 [95% CI: 1.1-1.4], P < 0.0001). Analyses of the propensity score-matched subpopulations also confirmed our findings. Risk factors for CSC in SA patients included male gender, age ≤50 years, higher income, presence of heart disease, absence of chronic pulmonary disease, and presence of liver disease. In SA patients, those who had received continuous positive airway pressure titration had a significantly lower incidence rate of CSC than the others. CONCLUSION: Our study revealed a significantly higher incidence rate of CSC in SA patients compared with the control subjects.
PURPOSE: To identify the association between sleep apnea (SA) and central serous chorioretinopathy (CSC). METHODS: In this nationwide population-based study using the Taiwan National Health Insurance Database, we enrolled adult patients with a diagnosis of SA and matched each patient to 30 age- and gender-matched control subjects without any SA diagnosis. Using Poisson regression analyses, the incidence rate of CSC was compared between SApatients and control subjects. RESULTS: A total of 10,753 SApatients and 322,590 control subjects were identified. After adjusting for age, gender, residency, income level, and comorbidities, the incidence rate of CSC was significantly higher in SApatients than in the control subjects (adjusted incident rate ratio for probable SA: 1.2 [95% CI: 1.1-1.4], P < 0.0001). Analyses of the propensity score-matched subpopulations also confirmed our findings. Risk factors for CSC in SApatients included male gender, age ≤50 years, higher income, presence of heart disease, absence of chronic pulmonary disease, and presence of liver disease. In SApatients, those who had received continuous positive airway pressure titration had a significantly lower incidence rate of CSC than the others. CONCLUSION: Our study revealed a significantly higher incidence rate of CSC in SApatients compared with the control subjects.