Julie Yu1, Jessica Pudwell1, Natalie Dayan2, Graeme N Smith1. 1. Department of Obstetrics and Gynecology, Kingston Health Sciences Center, Queen's University, Kingston, Canada. 2. Department of Medicine, McGill University, Montreal, Canada.
Abstract
Background: Breastfeeding is associated with lower cardiovascular (CV) risk over the long-term, however, less is known about its immediate effects among women with a recent complicated pregnancy. The objective of this study is to investigate the short-term effects of breastfeeding on markers of cardiovascular disease risk among women ∼6 months after a pregnancy complicated by a hypertensive disorder, gestational diabetes, intrauterine growth restriction, abruption, or preterm birth. Materials and Methods: Our cross-sectional analysis includes 622 women seen at 6 months postpartum (interquartile range: 5.7-6.7) between November 2011 and December 2017 at a tertiary care center. Self-reported breastfeeding status and measured CV risk factors were assessed at the same visit. CV risk factors were compared between women who did not breastfeed (n = 100, 16%), those who breastfed for less than 6 months (n = 315, 51%), and those who breastfed for 6 months or more (n = 207, 33%) using multivariate logistic and linear regression. Results: Increased breastfeeding duration significantly decreased the likelihood of metabolic syndrome (adjusted odds ratio [95% confidence interval; CI]: 0.89 [0.79-0.99]), abnormal fasting glucose (0.79 [0.64-0.96]), and ratio of total cholesterol to high-density lipoprotein-cholesterol (HDL-C) (0.86 [0.78-0.95]). Furthermore, body mass index (estimated beta coefficients [95% CI] -0.10 [-0.18 to -0.02]), fasting glucose (-0.05 [-0.08 to -0.02]), triglycerides (-0.07 [-0.10 to -0.04]), and ratio of total cholesterol to HDL-C (-0.06 [-0.10 to -0.03]) also decreased with increased breastfeeding duration, while HDL-C increased (0.02 [-0.01 to -0.04]). Conclusions: Our findings suggest that breastfeeding is associated with decreased indicators of CV risk in a cohort of women with recent pregnancy complication.
Background: Breastfeeding is associated with lower cardiovascular (CV) risk over the long-term, however, less is known about its immediate effects among women with a recent complicated pregnancy. The objective of this study is to investigate the short-term effects of breastfeeding on markers of cardiovascular disease risk among women ∼6 months after a pregnancy complicated by a hypertensive disorder, gestational diabetes, intrauterine growth restriction, abruption, or preterm birth. Materials and Methods: Our cross-sectional analysis includes 622 women seen at 6 months postpartum (interquartile range: 5.7-6.7) between November 2011 and December 2017 at a tertiary care center. Self-reported breastfeeding status and measured CV risk factors were assessed at the same visit. CV risk factors were compared between women who did not breastfeed (n = 100, 16%), those who breastfed for less than 6 months (n = 315, 51%), and those who breastfed for 6 months or more (n = 207, 33%) using multivariate logistic and linear regression. Results: Increased breastfeeding duration significantly decreased the likelihood of metabolic syndrome (adjusted odds ratio [95% confidence interval; CI]: 0.89 [0.79-0.99]), abnormal fasting glucose (0.79 [0.64-0.96]), and ratio of total cholesterol to high-density lipoprotein-cholesterol (HDL-C) (0.86 [0.78-0.95]). Furthermore, body mass index (estimated beta coefficients [95% CI] -0.10 [-0.18 to -0.02]), fasting glucose (-0.05 [-0.08 to -0.02]), triglycerides (-0.07 [-0.10 to -0.04]), and ratio of total cholesterol to HDL-C (-0.06 [-0.10 to -0.03]) also decreased with increased breastfeeding duration, while HDL-C increased (0.02 [-0.01 to -0.04]). Conclusions: Our findings suggest that breastfeeding is associated with decreased indicators of CV risk in a cohort of women with recent pregnancy complication.
Authors: Anna C O'Kelly; Erin D Michos; Chrisandra L Shufelt; Jane V Vermunt; Margo B Minissian; Odayme Quesada; Graeme N Smith; Janet W Rich-Edwards; Vesna D Garovic; Samar R El Khoudary; Michael C Honigberg Journal: Circ Res Date: 2022-02-17 Impact factor: 17.367
Authors: Eunjung Choi; Brigitte Kazzi; Bhavya Varma; Alexandra R Ortengren; Anum S Minhas; Arthur Jason Vaught; Wendy L Bennett; Jennifer Lewey; Erin D Michos Journal: Curr Cardiovasc Risk Rep Date: 2022-09-21
Authors: Zhongzheng Niu; Christine H Naya; Lorena Reynaga; Claudia M Toledo-Corral; Mark Johnson; Tingyu Yang; Brendan Grubbs; Nathana Lurvey; Deborah Lerner; Genevieve F Dunton; Rima Habre; Carrie V Breton; Theresa M Bastain; Shohreh F Farzan Journal: Int J Environ Res Public Health Date: 2022-03-04 Impact factor: 3.390