Yakaiah Vangoori1, Anusha Dakshinamoorthi2, S Kavimani3. 1. Sri Ramachandra Institute of Higher Education and Research (SRIHER)-Chennai & Santhiram Medical College, Nandyal, AP, India. 2. Sri Ramachandra Institute of Higher Education and Research (SRIHER)-Chennai, Tamilnadu, India. 3. Mother Theresa Post Graduate and Research Institute of Health Sciences, Pondicherry, India.
Abstract
Objective:The objective of the present study was to evaluate the antioxidant and lipase inhibitory potential of various extracts of Myristica fragrans (in vitro). Material and methods:Ethanolic extracts of Myristica fragrans were studied for their free radical scavenging and lipase inhibitory potentials by using porcine lipase, PNPB and DPPH. All results were obtained by applying active formulas and calculating the percentage of inhibition. Results: Among all extracts, Myristica fragrans ethanolic extract has shown the strongest pancreatic lipase inhibitory activity at 100 ìg/mL (66.24%), with the closest potency to tthat of the standard drug, Orlistat (81.57%). This extract has also exhibited a potent antioxidant activity. The findings of the present study clearly showed that DPPH free radical scavenging activity of MFE produced 88% inhibition at 5 mg/mL as compared to standard ascorbic acid, which was 90%. Conclusions:Ethanolic extracts of Myristica fragrans had a marked PL inhibitory action and antioxidant effect. Therefore, based on this research evidence, they could be aternatively used for obesity treatment.
Objective:The objective of the present study was to evaluate the antioxidant and lipase inhibitory potential of various extracts of Myristica fragrans (in vitro). Material and methods:Ethanolic extracts of Myristica fragrans were studied for their free radical scavenging and lipase inhibitory potentials by using porcine lipase, PNPB and DPPH. All results were obtained by applying active formulas and calculating the percentage of inhibition. Results: Among all extracts, Myristica fragrans ethanolic extract has shown the strongest pancreatic lipase inhibitory activity at 100 ìg/mL (66.24%), with the closest potency to tthat of the standard drug, Orlistat (81.57%). This extract has also exhibited a potent antioxidant activity. The findings of the present study clearly showed that DPPH free radical scavenging activity of MFE produced 88% inhibition at 5 mg/mL as compared to standard ascorbic acid, which was 90%. Conclusions:Ethanolic extracts of Myristica fragrans had a marked PL inhibitory action and antioxidant effect. Therefore, based on this research evidence, they could be aternatively used for obesity treatment.
Authors: B R Eesha; V Mohanbabu Amberkar; K Meena Kumari; Babu Sarath; M Vijay; M Lalit; R Rajput Journal: Asian Pac J Trop Med Date: 2011-06 Impact factor: 1.226
Authors: Eun Mi Lee; Seung Sik Lee; Byung Yeoup Chung; Jae-Young Cho; In Chul Lee; So Ra Ahn; Soo Jeung Jang; Tae Hoon Kim Journal: Molecules Date: 2010-11-16 Impact factor: 4.411