Literature DB >> 17080028

The obesity pipeline: current strategies in the development of anti-obesity drugs.

Dunstan Cooke1, Steve Bloom.   

Abstract

This review provides a summary of currently available pharmaceutical therapies for the treatment of obesity, along with an overview of the pipeline of products currently in development, and the key mechanisms on which the major development candidates are based. In particular, the recent increase in understanding of the role of gut peptides in energy homeostasis is highlighted as a promising source of potential future obesity therapies.

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Year:  2006        PMID: 17080028     DOI: 10.1038/nrd2136

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


  43 in total

1.  A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys.

Authors:  Kirstin F Barnhart; Dawn R Christianson; Patrick W Hanley; Wouter H P Driessen; Bruce J Bernacky; Wallace B Baze; Sijin Wen; Mei Tian; Jingfei Ma; Mikhail G Kolonin; Pradip K Saha; Kim-Anh Do; James F Hulvat; Juri G Gelovani; Lawrence Chan; Wadih Arap; Renata Pasqualini
Journal:  Sci Transl Med       Date:  2011-11-09       Impact factor: 17.956

2.  Drug treatment for obesity in the post-sibutramine era.

Authors:  Bernard M Y Cheung
Journal:  Drug Saf       Date:  2011-08-01       Impact factor: 5.606

Review 3.  The endocannabinoid system: a new pharmacological target for obesity treatment?

Authors:  Jia Hu; Chao Zhu; Mao Huang
Journal:  Neurosci Bull       Date:  2009-06       Impact factor: 5.203

Review 4.  Inflammatory lipid mediators in adipocyte function and obesity.

Authors:  Abishek Iyer; David P Fairlie; Johannes B Prins; Bruce D Hammock; Lindsay Brown
Journal:  Nat Rev Endocrinol       Date:  2010-02       Impact factor: 43.330

5.  Prieurianin Causes Weight Loss in Diet-Induced Obese Mice and Inhibits Adipogenesis in Cultured Preadipocytes.

Authors:  Ahmed Kablan; Rudel A Saunders; Maria Szkudlarek-Mikho; Andrew J B Chin; Raul M Bosio; Kazuyuki Fujii; Joseph Shapiro; Khew-Voon Chin
Journal:  J Diabetes Metab       Date:  2010-09-29

6.  Pharmacotherapy for obesity.

Authors:  Mingfang Li; Bernard M Y Cheung
Journal:  Br J Clin Pharmacol       Date:  2009-12       Impact factor: 4.335

Review 7.  Managing cardiovascular risk in overweight children and adolescents.

Authors:  Sarita Dhuper; Sujatha Buddhe; Sunil Patel
Journal:  Paediatr Drugs       Date:  2013-06       Impact factor: 3.022

Review 8.  Fat synthesis and adiposity regulation in Caenorhabditis elegans.

Authors:  Jennifer L Watts
Journal:  Trends Endocrinol Metab       Date:  2009-01-31       Impact factor: 12.015

Review 9.  Pharmacotherapeutic targeting of the endocannabinoid signaling system: drugs for obesity and the metabolic syndrome.

Authors:  V Kiran Vemuri; David R Janero; Alexandros Makriyannis
Journal:  Physiol Behav       Date:  2007-11-21

Review 10.  The changing shape of type 2 diabetes.

Authors:  Stephen A Brunton
Journal:  Medscape J Med       Date:  2008-06-18
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