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Literature DB >> 31797391

A destabilised metabolic niche provokes loss of a subpopulation of aged muscle stem cells.

Brendan Evano^1,2, Shahragim Tajbakhsh¹.

Abstract

Ageing is a multi-factorial condition that results in a gradual decline in tissue and organ function. Systemic, local and intrinsic factors play major roles in this process that also results in a decline in stem cell number and function. In this issue of The EMBO Journal, Li et al (2019) show that a subpopulation of mouse muscle stem cells is depleted in aged mice through loss of niche-derived granulocyte colony-stimulating factor (G-CSF).

Entities: Gene Species

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Year: 2019 PMID： 31797391 PMCID： PMC6912036 DOI： 10.15252/embj.2019103924

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

11 in total

1. G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy.

Authors: Nozomi Hayashiji; Shinsuke Yuasa; Yuko Miyagoe-Suzuki; Mie Hara; Naoki Ito; Hisayuki Hashimoto; Dai Kusumoto; Tomohisa Seki; Shugo Tohyama; Masaki Kodaira; Akira Kunitomi; Shin Kashimura; Makoto Takei; Yuki Saito; Shinichiro Okata; Toru Egashira; Jin Endo; Toshikuni Sasaoka; Shin'ichi Takeda; Keiichi Fukuda
Journal: Nat Commun Date: 2015-04-13 Impact factor: 14.919

2. Muscle-secreted granulocyte colony-stimulating factor functions as metabolic niche factor ameliorating loss of muscle stem cells in aged mice.

Authors: Hu Li; Qian Chen; Changyin Li; Ran Zhong; Yixia Zhao; Qianying Zhang; Weimin Tong; Dahai Zhu; Yong Zhang
Journal: EMBO J Date: 2019-11-18 Impact factor: 11.598

3. A destabilised metabolic niche provokes loss of a subpopulation of aged muscle stem cells.

Authors: Brendan Evano; Shahragim Tajbakhsh
Journal: EMBO J Date: 2019-12-04 Impact factor: 11.598

4. Autophagy maintains stemness by preventing senescence.

Authors: Laura García-Prat; Marta Martínez-Vicente; Eusebio Perdiguero; Laura Ortet; Javier Rodríguez-Ubreva; Elena Rebollo; Vanessa Ruiz-Bonilla; Susana Gutarra; Esteban Ballestar; Antonio L Serrano; Marco Sandri; Pura Muñoz-Cánoves
Journal: Nature Date: 2016-01-07 Impact factor: 49.962

A destabilised metabolic niche provokes loss of a subpopulation of aged muscle stem cells.

1. G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy.

2. Muscle-secreted granulocyte colony-stimulating factor functions as metabolic niche factor ameliorating loss of muscle stem cells in aged mice.

3. A destabilised metabolic niche provokes loss of a subpopulation of aged muscle stem cells.

4. Autophagy maintains stemness by preventing senescence.

5. Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis.

Review 6. Skeletal muscle stem cells in comfort and stress.

7. Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells.

8. Inhibition of JAK-STAT signaling stimulates adult satellite cell function.

9. Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division.

10. STAT3 signaling controls satellite cell expansion and skeletal muscle repair.

1. A destabilised metabolic niche provokes loss of a subpopulation of aged muscle stem cells.