Literature DB >> 31786185

Emerging therapeutic potential of the iridoid molecule, asperuloside: A snapshot of its underlying molecular mechanisms.

Yinghan Chan1, Sin Wi Ng1, Joycelin Zhu Xin Tan1, Gaurav Gupta2, Murtaza M Tambuwala3, Hamid A Bakshi3, Harish Dureja4, Kamal Dua5, Muhammad Ishaq6, Vanni Caruso7, Dinesh Kumar Chellappan8.   

Abstract

Over the years, the attention of researchers in the field of modern drug discovery and development has become further intense on the identification of active compounds from plant sources and traditional remedies, as they exhibit higher therapeutic efficacies and improved toxicological profiles. Among the large diversity of plant extracts that have been discovered and explored for their potential therapeutic benefits, asperuloside, an iridoid glycoside, has been proven to provide promising effects as a therapeutic agent for several diseases. Although, this potent substance exists in several genera, it is primarily found in plants belonging to the genus Eucommia. Recent decades have seen a surge in the research on Asperuloside, making it one of the most studied natural products in the field of medicine and pharmacology. In this review, we have attempted to study the various reported mechanisms of asperuloside that form the basis of its wide spectrum of pharmacological activities.
Copyright © 2019 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Anti-Cancer; Anti-Obesity; Anti-bacterial; Anti-inflammatory; Asperuloside; Laxative

Mesh:

Substances:

Year:  2019        PMID: 31786185     DOI: 10.1016/j.cbi.2019.108911

Source DB:  PubMed          Journal:  Chem Biol Interact        ISSN: 0009-2797            Impact factor:   5.192


  5 in total

1.  Evaluation of the Antioxidant, Anti-Inflammatory and Cytoprotective Activities of Halophyte Extracts against Mycotoxin Intoxication.

Authors:  Nolwenn Hymery; Xavier Dauvergne; Halima Boussaden; Stéphane Cérantola; Dorothée Faugère; Christian Magné
Journal:  Toxins (Basel)       Date:  2021-04-27       Impact factor: 4.546

2.  Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice.

Authors:  Muhammad Ishaq; Duyen Tran; Yijia Wu; Krzysztof Nowak; Bianca J Deans; Joycelin Tan Zhu Xin; Hui Lin Loh; Wen Ying Ng; Chin Wen Yee; Benjamin Southam; Silvia Vicenzi; Cameron Randall; Cheng Yang; Ee Tan; Manideepika Pasupuleti; Avneet Kaur Grewal; Tauseef Ahmad; Madhur Shastri; Carmelo Vicario; Maurizio Ronci; Mariachiara Zuccarini; Martin Bleasel; Paul Scowen; William Raffaeli; Gianvicenzo D'Andrea; Dinesh Kumar Chellappan; Glenn Jacobson; Alex C Bissember; Jason A Smith; Raj Eri; Juan Canales; Miguel Iglesias; Nuri Guven; Vanni Caruso
Journal:  Front Endocrinol (Lausanne)       Date:  2021-04-13       Impact factor: 5.555

3.  Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects.

Authors:  Si-Jing Hu; Gang Cheng; Hao Zhou; Qi Zhang; Quan-Long Zhang; Yang Wang; Yi Shen; Chen-Xia Lian; Xue-Qin Ma; Qiao-Yan Zhang; Lu-Ping Qin
Journal:  Molecules       Date:  2022-01-21       Impact factor: 4.411

4.  Extracts of Knoxia roxburghii (Spreng.) M. A. Rau Induce Apoptosis in Human MCF-7 Breast Cancer Cells via Mitochondrial Pathways.

Authors:  Xiao-Jiao Chen; Xin-Ying Pu; Xue-Mei Pu; Xue Li; Zhi-Bo Liu; Mi-Jia Mei; Xin-Ge Wang; Fan Zhang; Bin Qiu; Jie Yu
Journal:  Molecules       Date:  2022-09-29       Impact factor: 4.927

5.  Metabolomic Profiling and Immunomodulatory Activity of a Polyherbal Combination in Cyclophosphamide-Induced Immunosuppressed Mice.

Authors:  Sultan Zahiruddin; Abida Parveen; Washim Khan; Mohammad Ibrahim; Muzamil Y Want; Rabea Parveen; Sayeed Ahmad
Journal:  Front Pharmacol       Date:  2022-01-03       Impact factor: 5.810

  5 in total

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