Balamuralikrishnan Balasubramanian1, Arun Meyyazhagan2, Ashok Jeyaram Chinnappan3, Karthick Kumar Alagamuthu4, Sureshkumar Shanmugam5, Naif Abdullah Al-Dhabi6, Abdul Kareem Mohammed Ghilan6, Veeramuthu Duraipandiyan6, Mariadhas Valan Arasu7. 1. Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore-46, Tamil Nadu, India; Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, Republic of Korea. Electronic address: bala.m.k@sejong.ac.kr. 2. Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore-46, Tamil Nadu, India; EuroEspes Biomedical Research Centre, Institute of Medical Science and Genomic Medicine, Coruna, Spain. Electronic address: arun47biotech@gmail.com. 3. Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore-46, Tamil Nadu, India. 4. Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore-46, Tamil Nadu, India; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China. 5. Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore-46, Tamil Nadu, India; Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration, 1500, Wanju-gun 55365, Republic of Korea. 6. Department of Botany and Microbiology, College of Sciences, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. 7. Department of Botany and Microbiology, College of Sciences, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; Xavier Research Foundation, St. Xavier's College, Palayamkottai, Thirunelveli, 627002, Tamil Nadu, India.
Abstract
BACKGROUND: The present investigation of genotoxicity of lead (Pb) among workers exposed to inorganic Pb environment, which appears to be first of its kind in South India, was undertaken to assess the seriousness, the ill effects of health contributed by this serious environmental pollutant. METHODS: A total of 144 samples comprising of exposed (n=72), and control (n=72) subjects were screened. Demographic data and their associated health levels were undertaken by means of a questionnaire. The blood samples collected were subjected to chromosomal analysis, micronuclei assessment and comet assay. RESULTS: A higher level of Pb was quantified in the blood samples of all exposed subjects. An overview of the genotoxic assessment helped us understand parameters such as age do not affect or bring about any difference in the genotoxic potential of the exposed and control subjects. The only signification feature that resulted in an enhanced genotoxic potential was the years of exposure to the Pb environment that accumulated the dosage of Pb over the years. CONCLUSION: The high positivity of genotoxic potential of Pb in a country like India highlights the need for labelling hazardous metals in paint containers as a means to assure strict regulations.
BACKGROUND: The present investigation of genotoxicity of lead (Pb) among workers exposed to inorganic Pb environment, which appears to be first of its kind in South India, was undertaken to assess the seriousness, the ill effects of health contributed by this serious environmental pollutant. METHODS: A total of 144 samples comprising of exposed (n=72), and control (n=72) subjects were screened. Demographic data and their associated health levels were undertaken by means of a questionnaire. The blood samples collected were subjected to chromosomal analysis, micronuclei assessment and comet assay. RESULTS: A higher level of Pb was quantified in the blood samples of all exposed subjects. An overview of the genotoxic assessment helped us understand parameters such as age do not affect or bring about any difference in the genotoxic potential of the exposed and control subjects. The only signification feature that resulted in an enhanced genotoxic potential was the years of exposure to the Pb environment that accumulated the dosage of Pb over the years. CONCLUSION: The high positivity of genotoxic potential of Pb in a country like India highlights the need for labelling hazardous metals in paint containers as a means to assure strict regulations.
Authors: Mian H R Mahmood; Muhammad Abdul Qayyum; Farhan Yaseen; Tahir Farooq; Zahid Farooq; Muhammad Yaseen; Ahmad Irfan; Khawaja Muddassir; Muhammad Nadeem Zafar; Muhammad Tariq Qamar; Arshad Mehmood Abbasi; Hai-Yang Liu Journal: Biol Trace Elem Res Date: 2021-02-26 Impact factor: 3.738