Literature DB >> 31784827

[Acute stroke treatment in old age].

Frank Erbguth1.   

Abstract

In patients over 80 years old, 4 of the 5 evidence-based acute treatments of ischemic stroke, i.e. stroke unit treatment, antiplatelet therapy, intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are effective but with a higher morbidity than in younger patients. The indications for the more invasive forms of treatment, such as IVT and MT are given in principle but have to be oriented to the individual patient comorbidities. In the case of failure of these procedures a consistent therapeutic target change to palliative measures is appropriate. Decompressive craniotomy in space-occupying media infarction can be indicated up to the relative age limit of 60 years and absolute age limit of 70 years. Patients over 80 years often do not undergo IVT or MT. Although the German approval for alteplase within the framework of IVT over the age of 80 years suggests a careful and critical review of the indications, its use is generally recommended.

Entities:  

Keywords:  Cerebral ischemia; Decompression, surgical; Intracerebral hemorrhage; Platelet aggregation inhibitors; Thrombolytic therapy

Mesh:

Year:  2019        PMID: 31784827     DOI: 10.1007/s00391-019-01655-8

Source DB:  PubMed          Journal:  Z Gerontol Geriatr        ISSN: 0948-6704            Impact factor:   1.281


  32 in total

Review 1.  Intravenous thrombolysis in stroke patients of > or = 80 versus < 80 years of age--a systematic review across cohort studies.

Authors:  Stefan T Engelter; Leo H Bonati; Philippe A Lyrer
Journal:  Age Ageing       Date:  2006-11       Impact factor: 10.668

Review 2.  [End-of-life Decisions].

Authors:  F J Erbguth; L Erbguth
Journal:  Dtsch Med Wochenschr       Date:  2016-10-04       Impact factor: 0.628

3.  Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials.

Authors:  Katayoun Vahedi; Jeannette Hofmeijer; Eric Juettler; Eric Vicaut; Bernard George; Ale Algra; G Johan Amelink; Peter Schmiedeck; Stefan Schwab; Peter M Rothwell; Marie-Germaine Bousser; H Bart van der Worp; Werner Hacke
Journal:  Lancet Neurol       Date:  2007-03       Impact factor: 44.182

4.  Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke.

Authors:  Henry Ma; Bruce C V Campbell; Mark W Parsons; Leonid Churilov; Christopher R Levi; Chung Hsu; Timothy J Kleinig; Tissa Wijeratne; Sami Curtze; Helen M Dewey; Ferdinand Miteff; Chon-Haw Tsai; Jiunn-Tay Lee; Thanh G Phan; Neil Mahant; Mu-Chien Sun; Martin Krause; Jonathan Sturm; Rohan Grimley; Chih-Hung Chen; Chaur-Jong Hu; Andrew A Wong; Deborah Field; Yu Sun; P Alan Barber; Arman Sabet; Jim Jannes; Jiann-Shing Jeng; Benjamin Clissold; Romesh Markus; Ching-Huang Lin; Li-Ming Lien; Christopher F Bladin; Søren Christensen; Nawaf Yassi; Gagan Sharma; Andrew Bivard; Patricia M Desmond; Bernard Yan; Peter J Mitchell; Vincent Thijs; Leeanne Carey; Atte Meretoja; Stephen M Davis; Geoffrey A Donnan
Journal:  N Engl J Med       Date:  2019-05-09       Impact factor: 91.245

5.  Clinical Characteristics and Outcomes of Intracerebral Hemorrhage in Very Elderly.

Authors:  Yasuteru Inoue; Fumio Miyashita; Kazuo Minematsu; Kazunori Toyoda
Journal:  J Stroke Cerebrovasc Dis       Date:  2017-10-12       Impact factor: 2.136

Review 6.  [FEES in the stroke unit: recommendations for implementation in the clinical routine].

Authors:  R Dziewas; O Busse; J Glahn; M Grond; G F Hamann; G W Ickenstein; D G Nabavi; M Prosiegel; W-R Schäbitz; P D Schellinger; S Stanschus
Journal:  Nervenarzt       Date:  2013-06       Impact factor: 1.214

7.  Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive.

Authors:  Nishant K Mishra; Niaz Ahmed; Grethe Andersen; José A Egido; Perttu J Lindsberg; Peter A Ringleb; Nils G Wahlgren; Kennedy R Lees
Journal:  BMJ       Date:  2010-11-23

Review 8.  Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010.

Authors:  Valery L Feigin; Mohammad H Forouzanfar; Rita Krishnamurthi; George A Mensah; Myles Connor; Derrick A Bennett; Andrew E Moran; Ralph L Sacco; Laurie Anderson; Thomas Truelsen; Martin O'Donnell; Narayanaswamy Venketasubramanian; Suzanne Barker-Collo; Carlene M M Lawes; Wenzhi Wang; Yukito Shinohara; Emma Witt; Majid Ezzati; Mohsen Naghavi; Christopher Murray
Journal:  Lancet       Date:  2014-01-18       Impact factor: 79.321

9.  Why are acute ischemic stroke patients not receiving IV tPA? Results from a national registry.

Authors:  Steven R Messé; Pooja Khatri; Mathew J Reeves; Eric E Smith; Jeffrey L Saver; Deepak L Bhatt; Maria V Grau-Sepulveda; Margueritte Cox; Eric D Peterson; Gregg C Fonarow; Lee H Schwamm
Journal:  Neurology       Date:  2016-09-14       Impact factor: 9.910

10.  Hemicraniectomy in older patients with extensive middle-cerebral-artery stroke.

Authors:  Eric Jüttler; Andreas Unterberg; Johannes Woitzik; Julian Bösel; Hemasse Amiri; Oliver W Sakowitz; Matthias Gondan; Petra Schiller; Ronald Limprecht; Steffen Luntz; Hauke Schneider; Thomas Pinzer; Carsten Hobohm; Jürgen Meixensberger; Werner Hacke
Journal:  N Engl J Med       Date:  2014-03-20       Impact factor: 91.245

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