Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Argonautes in Extracellular Vesicles: Artifact or Selected Cargo?

Literature DB >> 31784424

Argonautes in Extracellular Vesicles: Artifact or Selected Cargo?

Alissa M Weaver^1,2, James G Patton^3,4,5.

Abstract

Argonaute-2 (Ago2) is a key component of the RNA-induced silencing complex that mediates downregulation of mRNA by miRNAs. Its presence in extracellular vesicles (EV) has been postulated to be important for the activity of EV-carried miRNA in modulating gene expression in recipient cells. However, whether it is in fact contained within EVs or is instead an extravesicular contaminant is controversial. In this opinion piece, we argue that the ability to detect Ago2 in EVs is a result of multiple factors, including cell source, cell signaling control of Ago2 trafficking to EVs, experimental conditions, and detection methods. ©2019 American Association for Cancer Research.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2019 PMID： 31784424 PMCID： PMC7002258 DOI： 10.1158/0008-5472.CAN-19-2782

Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701

10 in total

1. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.

Authors: Sonia A Melo; Hikaru Sugimoto; Joyce T O'Connell; Noritoshi Kato; Alberto Villanueva; August Vidal; Le Qiu; Edward Vitkin; Lev T Perelman; Carlos A Melo; Anthony Lucci; Cristina Ivan; George A Calin; Raghu Kalluri
Journal: Cancer Cell Date: 2014-10-23 Impact factor: 31.743

2. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma.

Authors: Jason D Arroyo; John R Chevillet; Evan M Kroh; Ingrid K Ruf; Colin C Pritchard; Donald F Gibson; Patrick S Mitchell; Christopher F Bennett; Era L Pogosova-Agadjanyan; Derek L Stirewalt; Jonathan F Tait; Muneesh Tewari
Journal: Proc Natl Acad Sci U S A Date: 2011-03-07 Impact factor: 11.205

3. Reassessment of Exosome Composition.

Authors: Dennis K Jeppesen; Aidan M Fenix; Jeffrey L Franklin; James N Higginbotham; Qin Zhang; Lisa J Zimmerman; Daniel C Liebler; Jie Ping; Qi Liu; Rachel Evans; William H Fissell; James G Patton; Leonard H Rome; Dylan T Burnette; Robert J Coffey
Journal: Cell Date: 2019-04-04 Impact factor: 41.582

4. Characterization of extracellular circulating microRNA.

Authors: Andrey Turchinovich; Ludmila Weiz; Anne Langheinz; Barbara Burwinkel
Journal: Nucleic Acids Res Date: 2011-05-24 Impact factor: 16.971

5. The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling.

Authors: Jan Van Deun; Pieter Mestdagh; Raija Sormunen; Veronique Cocquyt; Karim Vermaelen; Jo Vandesompele; Marc Bracke; Olivier De Wever; An Hendrix
Journal: J Extracell Vesicles Date: 2014-09-18

6. Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90.

Authors: Terence N Bukong; Fatemeh Momen-Heravi; Karen Kodys; Shashi Bala; Gyongyi Szabo
Journal: PLoS Pathog Date: 2014-10-02 Impact factor: 6.823

7. Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction.

Authors: Matthew J Shurtleff; Morayma M Temoche-Diaz; Kate V Karfilis; Sayaka Ri; Randy Schekman
Journal: Elife Date: 2016-08-25 Impact factor: 8.140

8. Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria.

Authors: Pierre-Yves Mantel; Daisy Hjelmqvist; Michael Walch; Solange Kharoubi-Hess; Sandra Nilsson; Deepali Ravel; Marina Ribeiro; Christof Grüring; Siyuan Ma; Prasad Padmanabhan; Alexander Trachtenberg; Johan Ankarklev; Nicolas M Brancucci; Curtis Huttenhower; Manoj T Duraisingh; Ionita Ghiran; Winston P Kuo; Luis Filgueira; Roberta Martinelli; Matthias Marti
Journal: Nat Commun Date: 2016-10-10 Impact factor: 14.919

9. Secretion of an Argonaute protein by a parasitic nematode and the evolution of its siRNA guides.

Authors: Franklin Wang-Ngai Chow; Georgios Koutsovoulos; Cesaré Ovando-Vázquez; Kyriaki Neophytou; Jose R Bermúdez-Barrientos; Dominik R Laetsch; Elaine Robertson; Sujai Kumar; Julie M Claycomb; Mark Blaxter; Cei Abreu-Goodger; Amy H Buck
Journal: Nucleic Acids Res Date: 2019-04-23 Impact factor: 16.971

10. KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes.

Authors: Andrew J McKenzie; Daisuke Hoshino; Nan Hyung Hong; Diana J Cha; Jeffrey L Franklin; Robert J Coffey; James G Patton; Alissa M Weaver
Journal: Cell Rep Date: 2016-04-21 Impact factor: 9.423

10 in total

5 in total

Argonautes in Extracellular Vesicles: Artifact or Selected Cargo?

1. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.

2. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma.

3. Reassessment of Exosome Composition.

4. Characterization of extracellular circulating microRNA.

5. The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling.

6. Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90.

7. Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction.

8. Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria.

9. Secretion of an Argonaute protein by a parasitic nematode and the evolution of its siRNA guides.

10. KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes.

Review 1. Vesiclemia: counting on extracellular vesicles for glioblastoma patients.

Review 2. RNA and Protein Delivery by Cell-Secreted and Bioengineered Extracellular Vesicles.

3. Pentapartite fractionation of particles in oral fluids by differential centrifugation.

4. Argonaute-2 protects the neurovascular unit from damage caused by systemic inflammation.

Review 5. RNA packaging into extracellular vesicles: An orchestra of RNA-binding proteins?