Hao Wang1, Bin Song2, Ningrong Ye3, Jiliang Ren4, Xilin Sun5, Zedong Dai5, Yuan Zhang5, Bihong T Chen6. 1. Department of Radiology, Minhang Hospital, Fudan University, Shanghai, China; Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, CA, United States. 2. Department of Radiology, Minhang Hospital, Fudan University, Shanghai, China. Electronic address: songbin@fudan.edu.cn. 3. Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, CA, United States. 4. Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5. Department of Radiology, Minhang Hospital, Fudan University, Shanghai, China. 6. Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, CA, United States. Electronic address: Bechen@coh.org.
Abstract
PURPOSE: To investigate the predictive capability of machine learning-based multiparametric magnetic resonance (MR) imaging radiomics for evaluating the aggressiveness of papillary thyroid carcinoma (PTC) preoperatively. METHODS: This prospective study enrolled consecutive patients who underwent neck MR scans and subsequent thyroidectomy during the study interval. The diagnosis and aggressiveness of PTC were determined by pathological evaluation of thyroidectomy specimens. Thyroid nodules were segmented manually on the MR images, and radiomic features were then extracted. Predictive machine learning modelling was used to evaluate the prediction of PTC aggressiveness. Area under the receiver operating characteristic curve (AUC) values for the model performance were obtained for radiomic features, clinical characteristics, and combinations of radiomic features and clinical characteristics. RESULTS: The study cohort included 120 patients with pathology-confirmed PTC (training cohort: n = 96; testing cohort: n = 24). A total of 1393 features were extracted from T2-weighted, apparent diffusion coefficient (ADC) and contrast-enhanced T1-weighted MR images for each patient. The combination of Least Absolute Shrinkage and Selection Operator for radiomic feature selection and Gradient Boosting Classifier for classifying PTC aggressiveness achieving the AUC of 0.92. In contrast, clinical characteristics alone poorly predicted PTC aggressiveness, with an AUC of 0.56. CONCLUSIONS: Our study showed that machine learning-based multiparametric MR imaging radiomics could accurately distinguish aggressive from non-aggressive PTC preoperatively. This approach may be helpful for informing treatment strategies and prognosis of patients with aggressive PTC.
PURPOSE: To investigate the predictive capability of machine learning-based multiparametric magnetic resonance (MR) imaging radiomics for evaluating the aggressiveness of papillary thyroid carcinoma (PTC) preoperatively. METHODS: This prospective study enrolled consecutive patients who underwent neck MR scans and subsequent thyroidectomy during the study interval. The diagnosis and aggressiveness of PTC were determined by pathological evaluation of thyroidectomy specimens. Thyroid nodules were segmented manually on the MR images, and radiomic features were then extracted. Predictive machine learning modelling was used to evaluate the prediction of PTC aggressiveness. Area under the receiver operating characteristic curve (AUC) values for the model performance were obtained for radiomic features, clinical characteristics, and combinations of radiomic features and clinical characteristics. RESULTS: The study cohort included 120 patients with pathology-confirmed PTC (training cohort: n = 96; testing cohort: n = 24). A total of 1393 features were extracted from T2-weighted, apparent diffusion coefficient (ADC) and contrast-enhanced T1-weighted MR images for each patient. The combination of Least Absolute Shrinkage and Selection Operator for radiomic feature selection and Gradient Boosting Classifier for classifying PTC aggressiveness achieving the AUC of 0.92. In contrast, clinical characteristics alone poorly predicted PTC aggressiveness, with an AUC of 0.56. CONCLUSIONS: Our study showed that machine learning-based multiparametric MR imaging radiomics could accurately distinguish aggressive from non-aggressive PTC preoperatively. This approach may be helpful for informing treatment strategies and prognosis of patients with aggressive PTC.
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