Derek B Kosty1, Richard F Farmer2, John R Seeley3, Kathleen R Merikangas4, Daniel N Klein5, Jeff M Gau3, Susan C Duncan2, Peter M Lewinsohn2. 1. Oregon Research Institute, 1776 Millrace Drive, Eugene, OR 97403, USA; University of Oregon, College of Education, 1585 E 13th Ave, Eugene, OR 97403, USA. Electronic address: dkosty@ori.org. 2. Oregon Research Institute, 1776 Millrace Drive, Eugene, OR 97403, USA. 3. Oregon Research Institute, 1776 Millrace Drive, Eugene, OR 97403, USA; University of Oregon, College of Education, 1585 E 13th Ave, Eugene, OR 97403, USA. 4. National Institute of Mental Health, 35A Convent Drive, MSC #3720, Bethesda, MD 20892, USA. 5. Stony Brook University, Psychology B Building, Stony Brook, NY 11794, USA.
Abstract
OBJECTIVE: We investigated associations between the number of parents with histories of alcohol use disorder (AUD) and several offspring (proband) variables through age 30: occurrence of AUD and, separately, alcohol dependence; onset age of the initial AUD episode; time to recovery from the first AUD episode; number of distinct AUD episodes; and cumulative duration of AUD across episodes. METHODS: Offspring data were collected during four assessment waves of a longitudinal epidemiological study of psychiatric disorders with a regionally representative sample. The reference sample included 730 offspring with diagnostic data from at least one parent. Offspring were assessed with semi-structured diagnostic interviews between mid-adolescence and young adulthood and parents were assessed when offspring were approximately 24 years of age. RESULTS: As the number of parents with AUD increased, offspring risk for AUD and alcohol dependence also increased. Latent growth model results indicated that offspring AUD risk trajectories increase in severity as a function of the number of parents with AUD. This pattern of results was not observed for other AUD course-related features in offspring (i.e., number of distinct episodes; months required for recovery from initial episode; cumulative duration across episodes). CONCLUSIONS: The number of parents with a history of AUD is associated with overall offspring risk for AUD and alcohol dependence and elevated AUD risk trajectories through age 30. The number of parents with AUD may be a more relevant risk factor for onset-related characteristics of AUD in offspring than for its longitudinal course. Published by Elsevier Ltd.
OBJECTIVE: We investigated associations between the number of parents with histories of alcohol use disorder (AUD) and several offspring (proband) variables through age 30: occurrence of AUD and, separately, alcohol dependence; onset age of the initial AUD episode; time to recovery from the first AUD episode; number of distinct AUD episodes; and cumulative duration of AUD across episodes. METHODS: Offspring data were collected during four assessment waves of a longitudinal epidemiological study of psychiatric disorders with a regionally representative sample. The reference sample included 730 offspring with diagnostic data from at least one parent. Offspring were assessed with semi-structured diagnostic interviews between mid-adolescence and young adulthood and parents were assessed when offspring were approximately 24 years of age. RESULTS: As the number of parents with AUD increased, offspring risk for AUD and alcohol dependence also increased. Latent growth model results indicated that offspring AUD risk trajectories increase in severity as a function of the number of parents with AUD. This pattern of results was not observed for other AUD course-related features in offspring (i.e., number of distinct episodes; months required for recovery from initial episode; cumulative duration across episodes). CONCLUSIONS: The number of parents with a history of AUD is associated with overall offspring risk for AUD and alcohol dependence and elevated AUD risk trajectories through age 30. The number of parents with AUD may be a more relevant risk factor for onset-related characteristics of AUD in offspring than for its longitudinal course. Published by Elsevier Ltd.
Entities:
Keywords:
Alcohol use disorders (AUD); Clinical features; Number of parents; Parental AUD; Trajectories
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