Literature DB >> 31782941

Beam commissioning of the first compact proton therapy system with spot scanning and dynamic field collimation.

Gloria Vilches-Freixas1, Mirko Unipan1, Ilaria Rinaldi1, Jonathan Martens1, Erik Roijen1, Isabel P Almeida1, Esther Decabooter1, Geert Bosmans1.   

Abstract

OBJECTIVES: To describe the measurements and to present the results of the beam commissioning and the beam model validation of a compact, gantry-mounted, spot scanning proton accelerator system with dynamic layer-by-layer field collimation.
METHODS: We performed measurements of depth dose distributions in water, spot and scanned field size in air at different positions from the isocenter plane, spot position over the 20 × 20 cm2 scanned area, beam monitor calibration in terms of absorbed dose to water and specific field collimation measurements at different gantry angles to commission the system. To validate the beam model in the treatment planning system (TPS), we measured spot profiles in water at different depths, absolute dose in water of single energy layers of different field sizes and inversely optimised spread-out Bragg peaks (SOBP) under normal and oblique beam incidence, field size and penumbra in water of SOBPs, and patient treatment specific quality assurance in homogeneous and heterogeneous phantoms.
RESULTS: Energy range, spot size, spot position and dose output were consistent at all gantry angles with 0.3 mm, 0.4 mm, 0.6 mm and 0.5% maximum deviations, respectively. Uncollimated spot size (one sigma) in air with an air-gap of 10 cm ranged from 4.1 to 16.4 mm covering a range from 32.2 to 1.9 cm in water, respectively. Absolute dose measurements were within 3% when comparing TPS and experimental data. Gamma pass rates >98% and >96% at 3%/3 mm were obtained when performing 2D dose measurements in homogeneous and in heterogeneous media, respectively. Leaf position was within ±1 mm at all gantry angles and nozzle positions.
CONCLUSIONS: Beam characterisation and machine commissioning results, and the exhaustive end-to-end tests performed to assess the proper functionality of the system, confirm that it is safe and accurate to treat patients. ADVANCES IN KNOWLEDGE: This is the first paper addressing the beam commissioning and the beam validation of a compact, gantry-mounted, pencil beam scanning proton accelerator system with dynamic layer-by-layer multileaf collimation.

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Year:  2019        PMID: 31782941      PMCID: PMC7066978          DOI: 10.1259/bjr.20190598

Source DB:  PubMed          Journal:  Br J Radiol        ISSN: 0007-1285            Impact factor:   3.039


  13 in total

1.  Dosimetric commissioning and quality assurance of scanned ion beams at the Italian National Center for Oncological Hadrontherapy.

Authors:  Alfredo Mirandola; S Molinelli; G Vilches Freixas; A Mairani; E Gallio; D Panizza; S Russo; M Ciocca; M Donetti; G Magro; S Giordanengo; R Orecchia
Journal:  Med Phys       Date:  2015-09       Impact factor: 4.071

2.  Selection of patients for radiotherapy with protons aiming at reduction of side effects: the model-based approach.

Authors:  Johannes A Langendijk; Philippe Lambin; Dirk De Ruysscher; Joachim Widder; Mike Bos; Marcel Verheij
Journal:  Radiother Oncol       Date:  2013-06-05       Impact factor: 6.280

3.  How costly is particle therapy? Cost analysis of external beam radiotherapy with carbon-ions, protons and photons.

Authors:  Andrea Peeters; Janneke P C Grutters; Madelon Pijls-Johannesma; Stefan Reimoser; Dirk De Ruysscher; Johan L Severens; Manuela A Joore; Philippe Lambin
Journal:  Radiother Oncol       Date:  2010-01-26       Impact factor: 6.280

4.  Experimental verification of IMPT treatment plans in an anthropomorphic phantom in the presence of delivery uncertainties.

Authors:  F Albertini; M Casiraghi; S Lorentini; B Rombi; A J Lomax
Journal:  Phys Med Biol       Date:  2011-06-27       Impact factor: 3.609

5.  Ion recombination correction factor in scanned light-ion beams for absolute dose measurement using plane-parallel ionisation chambers.

Authors:  S Rossomme; J Horn; S Brons; O Jäkel; A Mairani; M Ciocca; V Floquet; F Romano; D Rodriguez Garcia; S Vynckier; H Palmans
Journal:  Phys Med Biol       Date:  2017-05-15       Impact factor: 3.609

6.  Proton beam monitor chamber calibration.

Authors:  C Gomà; S Lorentini; D Meer; S Safai
Journal:  Phys Med Biol       Date:  2014-08-11       Impact factor: 3.609

7.  Determining Pion, the correction factor for recombination losses in an ionization chamber.

Authors:  M S Weinhous; J A Meli
Journal:  Med Phys       Date:  1984 Nov-Dec       Impact factor: 4.071

Review 8.  Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers.

Authors:  Roos Leroy; Nadia Benahmed; Frank Hulstaert; Nancy Van Damme; Dirk De Ruysscher
Journal:  Int J Radiat Oncol Biol Phys       Date:  2015-10-17       Impact factor: 7.038

9.  Commissioning and initial experience with the first clinical gantry-mounted proton therapy system.

Authors:  Tianyu Zhao; Baozhou Sun; Kevin Grantham; Leith Rankine; Bin Cai; Sreekrishna M Goddu; Lakshmi Santanam; Nels Knutson; Tiezhi Zhang; Michael Reilly; Beth Bottani; Jeffrey Bradley; Sasa Mutic; Eric E Klein
Journal:  J Appl Clin Med Phys       Date:  2016-03-08       Impact factor: 2.102

10.  Commissioning of the world's first compact pencil-beam scanning proton therapy system.

Authors:  Rajesh Pidikiti; Bijal C Patel; Matthew R Maynard; Joseph P Dugas; Joseph Syh; Narayan Sahoo; Hsinshun Terry Wu; Lane R Rosen
Journal:  J Appl Clin Med Phys       Date:  2017-11-20       Impact factor: 2.102

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  5 in total

1.  Automating proton treatment planning with beam angle selection using Bayesian optimization.

Authors:  Vicki T Taasti; Linda Hong; Jin Sup Andy Shim; Joseph O Deasy; Masoud Zarepisheh
Journal:  Med Phys       Date:  2020-05-27       Impact factor: 4.071

2.  Proton therapy special feature: introductory editorial.

Authors:  Kathryn D Held; Antony J Lomax; Esther G C Troost
Journal:  Br J Radiol       Date:  2020-03       Impact factor: 3.039

3.  Clinical Implementation of Proton Therapy Using Pencil-Beam Scanning Delivery Combined With Static Apertures.

Authors:  Christian Bäumer; Sandija Plaude; Dalia Ahmad Khalil; Dirk Geismar; Paul-Heinz Kramer; Kevin Kröninger; Christian Nitsch; Jörg Wulff; Beate Timmermann
Journal:  Front Oncol       Date:  2021-05-12       Impact factor: 6.244

Review 4.  Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy.

Authors:  Jacinta Yap; Andrea De Franco; Suzie Sheehy
Journal:  Front Oncol       Date:  2021-12-09       Impact factor: 5.738

5.  Innovations and the Use of Collimators in the Delivery of Pencil Beam Scanning Proton Therapy.

Authors:  Daniel E Hyer; Laura C Bennett; Theodore J Geoghegan; Martin Bues; Blake R Smith
Journal:  Int J Part Ther       Date:  2021-06-25
  5 in total

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