| Literature DB >> 31777944 |
Shennan Lu1, Jiyao Wang1, Farideh Chitsaz1, Myra K Derbyshire1, Renata C Geer1, Noreen R Gonzales1, Marc Gwadz1, David I Hurwitz1, Gabriele H Marchler1, James S Song1, Narmada Thanki1, Roxanne A Yamashita1, Mingzhang Yang1, Dachuan Zhang1, Chanjuan Zheng1, Christopher J Lanczycki1, Aron Marchler-Bauer1.
Abstract
As NLM's Conserved Domain Database (CDD) enters its 20th year of operations as a publicly available resource, CDD curation staff continues to develop hierarchical classifications of widely distributed protein domain families, and to record conserved sites associated with molecular function, so that they can be mapped onto user queries in support of hypothesis-driven biomolecular research. CDD offers both an archive of pre-computed domain annotations as well as live search services for both single protein or nucleotide queries and larger sets of protein query sequences. CDD staff has continued to characterize protein families via conserved domain architectures and has built up a significant corpus of curated domain architectures in support of naming bacterial proteins in RefSeq. These architecture definitions are available via SPARCLE, the Subfamily Protein Architecture Labeling Engine. CDD can be accessed at https://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml. Published by Oxford University Press on behalf of Nucleic Acids Research 2019.Entities:
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Year: 2020 PMID： 31777944 PMCID： PMC6943070 DOI： 10.1093/nar/gkz991
Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971