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Literature DB >> 31770436

Imetelstat inhibits growth of megakaryocyte colony-forming units from patients with essential thrombocythemia.

Gabriela M Baerlocher^1,2, Monika Haubitz², Thomas R Braschler^1,3, Claudio Brunold¹, Bart Burington⁴, Elisabeth Oppliger Leibundgut^1,2, Ning Go⁴.

Abstract

Entities: Disease Species

Mesh：

Substances：

Year: 2019 PMID： 31770436 PMCID： PMC6880912 DOI： 10.1182/bloodadvances.2019000167

Source DB: PubMed Journal: Blood Adv ISSN： 2473-9529

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15 in total

1. Response criteria for essential thrombocythemia and polycythemia vera: result of a European LeukemiaNet consensus conference.

Authors: Giovanni Barosi; Gunnar Birgegard; Guido Finazzi; Martin Griesshammer; Claire Harrison; Hans Carl Hasselbalch; Jean-Jacques Kiladjian; Eva Lengfelder; Mary Frances McMullin; Francesco Passamonti; John T Reilly; Alessandro M Vannucchi; Tiziano Barbui
Journal: Blood Date: 2009-03-10 Impact factor: 22.113

Review 2. Role of telomeres and telomerase in cancer.

Authors: Jerry W Shay; Woodring E Wright
Journal: Semin Cancer Biol Date: 2011-10-17 Impact factor: 15.707

3. Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP).

Authors: N W Kim; F Wu
Journal: Nucleic Acids Res Date: 1997-07-01 Impact factor: 16.971

4. Telomerase, hTERT and splice variants in patients with myelodysplastic syndromes.

Authors: Wen Dong; Yaqin Qian; Lili Yang
Journal: Leuk Res Date: 2014-04-28 Impact factor: 3.156

5. Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition.

Authors: Brittney-Shea Herbert; Ginelle C Gellert; Amelia Hochreiter; Krisztina Pongracz; Woodring E Wright; Daria Zielinska; Allison C Chin; Calvin B Harley; Jerry W Shay; Sergei M Gryaznov
Journal: Oncogene Date: 2005-08-04 Impact factor: 9.867

6. A Pilot Study of the Telomerase Inhibitor Imetelstat for Myelofibrosis.

Authors: Ayalew Tefferi; Terra L Lasho; Kebede H Begna; Mrinal M Patnaik; Darci L Zblewski; Christy M Finke; Rebecca R Laborde; Emnet Wassie; Lauren Schimek; Curtis A Hanson; Naseema Gangat; Xiaolin Wang; Animesh Pardanani
Journal: N Engl J Med Date: 2015-09-03 Impact factor: 91.245

7. A novel telomerase template antagonist (GRN163) as a potential anticancer agent.

Authors: Akira Asai; Yuko Oshima; Yoshihiro Yamamoto; Taka-aki Uochi; Hideaki Kusaka; Shiro Akinaga; Yoshinori Yamashita; Krisztina Pongracz; Ronald Pruzan; Ellen Wunder; Mieczyslaw Piatyszek; Shihong Li; Allison C Chin; Calvin B Harley; Sergei Gryaznov
Journal: Cancer Res Date: 2003-07-15 Impact factor: 12.701

5. Myelosuppression in Patients Treated with the Telomerase Inhibitor Imetelstat Is Not Mediated through Activation of Toll-Like Receptors.

Authors: Gabriela M Baerlocher; Joshua Rusbuldt; Jacqueline Bussolari; Fei Huang
Journal: Int J Mol Sci Date: 2020-09-08 Impact factor: 5.923

5 in total

Imetelstat inhibits growth of megakaryocyte colony-forming units from patients with essential thrombocythemia.

1. Response criteria for essential thrombocythemia and polycythemia vera: result of a European LeukemiaNet consensus conference.

Review 2. Role of telomeres and telomerase in cancer.

3. Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP).

4. Telomerase, hTERT and splice variants in patients with myelodysplastic syndromes.

5. Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition.

6. A Pilot Study of the Telomerase Inhibitor Imetelstat for Myelofibrosis.

7. A novel telomerase template antagonist (GRN163) as a potential anticancer agent.

8. Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo.

9. Specific association of human telomerase activity with immortal cells and cancer.

Review 10. Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms.

Review 1. Novel and combination therapies for polycythemia vera and essential thrombocythemia: the dawn of a new era.

2. Imetelstat Induces Leukemia Stem Cell Death in Pediatric Acute Myeloid Leukemia Patient-Derived Xenografts.

Review 3. Emerging agents and regimens for polycythemia vera and essential thrombocythemia.

4. CRISPR/Cas9-Mediated TERT Disruption in Cancer Cells.

5. Myelosuppression in Patients Treated with the Telomerase Inhibitor Imetelstat Is Not Mediated through Activation of Toll-Like Receptors.