Literature DB >> 31768179

Intra-Testicular Papaverine Injection for Testicular Salvage after Blunt Testicular Trauma: A Case Report.

Kevin Keating1, Paulette C Dreher2, Jason Levy2, Brian McGreen2, Daniel Edwards2, Susan Tarry2.   

Abstract

Blunt trauma is the most common mechanism of injury to the scrotum and testicle. Surgical exploration with primary repair, hematoma evacuation, and de-torsion are common surgical interventions. A 20-year-old male with no previous medical history presented after a high-speed motor vehicle collision. Ultrasonography demonstrated heterogeneous changes of the tunica albuginea and decreased arterial flow to bilateral testicles. He was subsequently taken to the operating room for surgical exploration, which revealed bilateral mottled testes with questionable viability. Papaverine was injected into each testicle, which resulted in visibly increased perfusion and subsequent preservation of the testicles.
Conclusion: Current evidence on the use of papaverine is isolated to testicular torsion. Additional research should be conducted on the use of papaverine in blunt testicular trauma. Papaverine injection may be a valuable treatment option when inadequate perfusion is observed intra-operatively.
Copyright © 2019 by S. Karger AG, Basel.

Entities:  

Keywords:  Papaverine; Testicular trauma

Year:  2019        PMID: 31768179      PMCID: PMC6873014          DOI: 10.1159/000499283

Source DB:  PubMed          Journal:  Curr Urol        ISSN: 1661-7649


  11 in total

Review 1.  Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage.

Authors:  James K Liu; William T Couldwell
Journal:  Neurocrit Care       Date:  2005       Impact factor: 3.210

2.  Testicular injuries.

Authors:  A S Cass; M Luxenberg
Journal:  Urology       Date:  1991-06       Impact factor: 2.649

3.  An atypical presentation of testicular torsion: a case report.

Authors:  Robert Jansen; Henry Fooks; Stanley Zaslau
Journal:  W V Med J       Date:  2013 Sep-Oct

4.  Inhibition by papaverine of cGMP and cAMP phosphodiesterases from the rat heart.

Authors:  C Lugnier; J C Stoclet
Journal:  Biochem Pharmacol       Date:  1974-11-01       Impact factor: 5.858

Review 5.  US of acute scrotal trauma: optimal technique, imaging findings, and management.

Authors:  Corinne Deurdulian; Carol A Mittelstaedt; Wui K Chong; Julia R Fielding
Journal:  Radiographics       Date:  2007 Mar-Apr       Impact factor: 5.333

Review 6.  Current options for the management of aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm: a comprehensive review of the literature.

Authors:  Guilherme Dabus; Raul G Nogueira
Journal:  Interv Neurol       Date:  2013-10

7.  Comparison of the protective effects of papaverine, lidocaine and verapamil on the sperm quality of the testis after induced torsion-detorsion in rats.

Authors:  Mehdi Shirazi; Ali Noorafshan; Saied Karbalay-Doust; Mohammad Ardeshiri; Mohammad Amin Afrasiabi; Ahmad Monabati
Journal:  Scand J Urol Nephrol       Date:  2010-04

Review 8.  SOP conservative (medical and mechanical) treatment of erectile dysfunction.

Authors:  Hartmut Porst; Arthur Burnett; Gerald Brock; Hussein Ghanem; Francois Giuliano; Sidney Glina; Wayne Hellstrom; Antonio Martin-Morales; Andrea Salonia; Ira Sharlip
Journal:  J Sex Med       Date:  2013-01       Impact factor: 3.802

9.  Mechanism of relaxant action of papaverine. VI. Sodium ion dependence of its effect on 45Ca-efflux in guinea-pig taenia coli.

Authors:  N Sunagane; T Ogawa; T Uruno; K Kubota
Journal:  Jpn J Pharmacol       Date:  1985-06

10.  The protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury.

Authors:  Mehmet Ali Karagoz; Omer Gokhan Doluoglu; Hatice Ünverdi; Berkan Resorlu; Mehmet Melih Sunay; Arif Demirbas; Tolga Karakan; Arif Aydin
Journal:  Int Braz J Urol       Date:  2018 May-Jun       Impact factor: 1.541

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  1 in total

1.  Testicular Rupture: The Other Nutcracker Syndrome.

Authors:  Francis Essien; Zachary Eagle; Joshua Tate; Austin Barber
Journal:  Clin Med Insights Case Rep       Date:  2022-02-11
  1 in total

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