Literature DB >> 31760080

The early stage peptidoglycan biosynthesis Mur enzymes are antibacterial and antisporulation drug targets for recurrent Clostridioides difficile infection.

Madhab Sapkota1, Ravi K R Marreddy2, Xiaoqian Wu2, Manish Kumar1, Julian G Hurdle3.   

Abstract

Sporulation during Clostridioides difficile infection (CDI) contributes to recurrent disease. Cell division and sporulation both require peptidoglycan biosynthesis. We show C. difficile growth and sporulation is attenuated by antisenses to murA and murC or the MurA inhibitor fosfomycin. Thus, targeting the early steps of peptidoglycan biosynthesis might reduce the onset of recurrent CDI.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antibiotic drug-targets; Heat-resistant spore cortex; Mur ligases; Peptidoglycan

Mesh：

Substances：

Year:  2019        PMID： 31760080      PMCID： PMC8811877          DOI： 10.1016/j.anaerobe.2019.102129

Source DB:  PubMed          Journal:  Anaerobe        ISSN： 1075-9964            Impact factor:   3.331


  22 in total

1.  Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteria.

Authors:  W Du; J R Brown; D R Sylvester; J Huang; A F Chalker; C Y So; D J Holmes; D J Payne; N G Wallis
Journal:  J Bacteriol       Date:  2000-08       Impact factor: 3.490

Review 2.  Structure, function and dynamics in the mur family of bacterial cell wall ligases.

Authors:  Clyde A Smith
Journal:  J Mol Biol       Date:  2006-08-01       Impact factor: 5.469

Review 3.  Challenges of antibacterial discovery.

Authors:  Lynn L Silver
Journal:  Clin Microbiol Rev       Date:  2011-01       Impact factor: 26.132

Review 4.  Microbiologic factors affecting Clostridium difficile recurrence.

Authors:  C H Chilton; D S Pickering; J Freeman
Journal:  Clin Microbiol Infect       Date:  2017-12-05       Impact factor: 8.067

5.  Decreased cure and increased recurrence rates for Clostridium difficile infection caused by the epidemic C. difficile BI strain.

Authors:  Laurica A Petrella; Susan P Sambol; Adam Cheknis; Kristin Nagaro; Yin Kean; Pamela S Sears; Farah Babakhani; Stuart Johnson; Dale N Gerding
Journal:  Clin Infect Dis       Date:  2012-04-20       Impact factor: 9.079

6.  Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules.

Authors:  Poochit Nonejuie; Michael Burkart; Kit Pogliano; Joe Pogliano
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-17       Impact factor: 11.205

7.  Localization of the Bacillus subtilis murB gene within the dcw cluster is important for growth and sporulation.

Authors:  Gonçalo Real; Adriano O Henriques
Journal:  J Bacteriol       Date:  2006-03       Impact factor: 3.490

8.  Prospects for flavonoid and related phytochemicals as nature-inspired treatments for Clostridium difficile infection.

Authors:  X Wu; M Z Alam; L Feng; L S Tsutsumi; D Sun; J G Hurdle
Journal:  J Appl Microbiol       Date:  2014-01       Impact factor: 3.772

Review 9.  Initiation of sporulation in Clostridium difficile: a twist on the classic model.

Authors:  Adrianne N Edwards; Shonna M McBride
Journal:  FEMS Microbiol Lett       Date:  2014-06-26       Impact factor: 2.742

10.  Fidaxomicin inhibits spore production in Clostridium difficile.

Authors:  Farah Babakhani; Laurent Bouillaut; Abraham Gomez; Pamela Sears; Ly Nguyen; Abraham L Sonenshein
Journal:  Clin Infect Dis       Date:  2012-08       Impact factor: 9.079
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  3 in total

1.  Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA.

Authors:  Jujun Zhou; John R Horton; Dan Yu; Ren Ren; Robert M Blumenthal; Xing Zhang; Xiaodong Cheng
Journal:  Epigenetics       Date:  2021-09-15       Impact factor: 4.861

2.  PrkA controls peptidoglycan biosynthesis through the essential phosphorylation of ReoM.

Authors:  Sabrina Wamp; Zoe J Rutter; Jeanine Rismondo; Claire E Jennings; Lars Möller; Richard J Lewis; Sven Halbedel
Journal:  Elife       Date:  2020-05-29       Impact factor: 8.140

3.  Potential of MurA Enzyme and GBAP in Fsr Quorum Sensing System as Antibacterial Drugs Target: In vitro and In silico Study of Antibacterial Compounds from Myrmecodia pendans.

Authors:  Eti Apriyanti; Mieke H Satari; Dikdik Kurnia
Journal:  Comb Chem High Throughput Screen       Date:  2021       Impact factor: 1.339
  3 in total

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