Literature DB >> 31758349

Moving Antiretroviral Adherence Assessments to the Modern Era: Correlations Among Three Novel Measures of Adherence.

Parya Saberi1, Deepalika Chakravarty2, Kristin Ming2, Dominique Legnitto2, Monica Gandhi2, Mallory O Johnson2, Torsten B Neilands2.   

Abstract

There is no gold standard for estimating antiretroviral therapy (ART) adherence. Feasible, acceptable, and objective measures that are cost- and time-effective are needed. US adults (N = 93) on ART for ≥ 3 months, having access to a mobile phone and internet, and willing to mail in self-collected hair samples, were recruited into a pilot study of remote adherence data collection methods. We examined the correlation of self-reported adherence and three objective remotely collected adherence measures: text-messaged photographs of pharmacy refill dates for pharmacy-refill-based adherence, text-messaged photographs of pills for pill-count-based adherence, and assays of home-collected hair samples for pharmacologic-based adherence. All measures were positively correlated. The strongest correlation was between pill-count- and pharmacy-refill-based adherence (r = 0.68; p < 0.001), and the weakest correlation was between self-reported adherence and hair drug concentrations (r = 0.14, p = 0.34). The three measures provide objective adherence data, are easy to collect, and are viable candidates for future HIV treatment and prevention research.

Entities:  

Keywords:  Adherence; HIV treatment; Hair drug concentrations; Pharmacy refill date; Pill count; Text message

Mesh：

Substances：

Year:  2020        PMID： 31758349      PMCID： PMC6996539          DOI： 10.1007/s10461-019-02744-w

Source DB:  PubMed          Journal:  AIDS Behav        ISSN： 1090-7165


  29 in total

1.  Non-adherence to highly active antiretroviral therapy predicts progression to AIDS.

Authors:  D R Bangsberg; S Perry; E D Charlebois; R A Clark; M Roberston; A R Zolopa; A Moss
Journal:  AIDS       Date:  2001-06-15       Impact factor: 4.177

Review 2.  A proposal for quality standards for measuring medication adherence in research.

Authors:  Ann Bartley Williams; K Rivet Amico; Carol Bova; Julie A Womack
Journal:  AIDS Behav       Date:  2013-01

Review 3.  Practical and conceptual challenges in measuring antiretroviral adherence.

Authors:  Karina M Berg; Julia H Arnsten
Journal:  J Acquir Immune Defic Syndr       Date:  2006-12-01       Impact factor: 3.731

4.  Value of patient self-report and plasma human immunodeficiency virus protease inhibitor level as markers of adherence to antiretroviral therapy: relationship to virologic response.

Authors:  M Duong; L Piroth; G Peytavin; F Forte; E Kohli; M Grappin; M Buisson; P Chavanet; H Portier
Journal:  Clin Infect Dis       Date:  2001-06-21       Impact factor: 9.079

Review 5.  Pre-exposure prophylaxis for HIV infection: how antiretroviral pharmacology helps to monitor and improve adherence.

Authors:  Jill Blumenthal; Richard Haubrich
Journal:  Expert Opin Pharmacother       Date:  2013-06-26       Impact factor: 3.889

6.  Antiretroviral drug concentrations in hair are associated with virologic outcomes among young people living with HIV in Tanzania.

Authors:  Zachary J Tabb; Blandina T Mmbaga; Monica Gandhi; Alexander Louie; Karen Kuncze; Hideaki Okochi; Aisa M Shayo; Elizabeth L Turner; Coleen K Cunningham; Dorothy E Dow
Journal:  AIDS       Date:  2018-06-01       Impact factor: 4.177

7.  Adherence to antiretroviral therapy assessed by unannounced pill counts conducted by telephone.

Authors:  Seth C Kalichman; Christina M Amaral; Heidi Stearns; Denise White; Jody Flanagan; Howard Pope; Chauncey Cherry; Demetria Cain; Lisa Eaton; Moira O Kalichman
Journal:  J Gen Intern Med       Date:  2007-03-28       Impact factor: 5.128

8.  Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya.

Authors:  Matthew D Hickey; Charles R Salmen; Robert A Tessler; Dan Omollo; Peter Bacchetti; Richard Magerenge; Brian Mattah; Marcus R Salmen; Daniel Zoughbie; Kathryn J Fiorella; Elvin Geng; Betty Njoroge; Chengshi Jin; Yong Huang; Elizabeth A Bukusi; Craig R Cohen; Monica Gandhi
Journal:  J Acquir Immune Defic Syndr       Date:  2014-07-01       Impact factor: 3.731

9.  Protease inhibitor levels in hair strongly predict virologic response to treatment.

Authors:  Monica Gandhi; Niloufar Ameli; Peter Bacchetti; Stephen J Gange; Kathryn Anastos; Alexandra Levine; Charles L Hyman; Mardge Cohen; Mary Young; Yong Huang; Ruth M Greenblatt
Journal:  AIDS       Date:  2009-02-20       Impact factor: 4.177

10.  Novel methods to estimate antiretroviral adherence: protocol for a longitudinal study.

Authors:  Parya Saberi; Kristin Ming; Dominique Legnitto; Torsten B Neilands; Monica Gandhi; Mallory O Johnson
Journal:  Patient Prefer Adherence       Date:  2018-06-18       Impact factor: 2.711
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  8 in total

Review 1.  Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention.

Authors:  Paul K Drain; Ashley R Bardon; Jane M Simoni; Tim R Cressey; Pete Anderson; Derin Sevenler; Ayokunle O Olanrewaju; Monica Gandhi; Connie Celum
Journal:  Curr HIV/AIDS Rep       Date:  2020-10       Impact factor: 5.071

2.  Relationship Dynamics are Associated with Self-Reported Adherence but not an Objective Adherence Measure in Malawi.

Authors:  Amy A Conroy; Stacey McKenna; Allison Ruark; Torsten B Neilands; Matthew Spinelli; Monica Gandhi
Journal:  AIDS Behav       Date:  2022-05-04

3.  Adherence to antiretroviral therapy thought package-refill among HIV+ persons at "D. Cotugno" hospital, Naples, Italy.

Authors:  Francesco Maria Fusco; Nadia Sangiovanni; Nunzia Papa; Nunzia Cuomo; Orsola Tambaro; Valentina Iodice; Vincenzo Bruner; Maria Aurora Carleo; Viviana Rizzo; Giulia Palmiero; Mariana Di Lorenzo; Micaela Spatarella; Rosaria Viglietti; Vincenzo Sangiovanni; Vincenzo Esposito
Journal:  Infez Med       Date:  2022-09-01

4.  A pilot pragmatic trial of a "what matters most"-based intervention targeting intersectional stigma related to being pregnant and living with HIV in Botswana.

Authors:  Lawrence H Yang; Evan L Eschliman; Haitisha Mehta; Supriya Misra; Ohemaa B Poku; Patlo Entaile; Timothy D Becker; Tadele Melese; Merrian J Brooks; Marlene Eisenberg; Melissa A Stockton; Karen Choe; Danielle Tal; Tingyu Li; Vivian F Go; Bruce G Link; Shathani Rampa; Valerie W Jackson; Gorata D Manyeagae; Tonya Arscott-Mills; Melody Goodman; Philip R Opondo; Ari R Ho-Foster; Michael B Blank
Journal:  AIDS Res Ther       Date:  2022-06-23       Impact factor: 2.846

5.  Income Inequality Is Associated With Low Cumulative Antiretroviral Adherence in Persons With Human Immunodeficiency Virus.

Authors:  Frances Vernon; Mary Morrow; Samantha MaWhinney; Ryan Coyle; Stacey Coleman; Lucas Ellison; Jia-Hua Zheng; Lane Bushman; Jennifer J Kiser; Omar Galárraga; Peter L Anderson; Jose Castillo-Mancilla
Journal:  Open Forum Infect Dis       Date:  2020-08-29       Impact factor: 3.835

6.  An Approach to Reducing Problematic Data in an ACASI Sexual Behavior Assessment.

Authors:  Lance M Pollack; John A Sauceda; Paul D Cotten; Johnny Blair; William J Woods
Journal:  J Sex Res       Date:  2020-06-05

7.  Simplifying TREAtment and Monitoring for HIV (STREAM HIV): protocol for a randomised controlled trial of point-of-care urine tenofovir and viral load testing to improve HIV outcomes.

Authors:  Ashley R Bardon; Jienchi Dorward; Yukteshwar Sookrajh; Fathima Sayed; Justice Quame-Amaglo; Cheryl Pillay; Erika Feutz; Hope Ngobese; Jane M Simoni; Monisha Sharma; Tim R Cressey; Monica Gandhi; Richard Lessells; Pravi Moodley; Nivashnee Naicker; Kogieleum Naidoo; Katherine Thomas; Connie Celum; Salim Abdool Karim; Nigel Garrett; Paul K Drain
Journal:  BMJ Open       Date:  2021-10-05       Impact factor: 3.006

8.  Research in the Time of Coronavirus: Continuing Ongoing Studies in the Midst of the COVID-19 Pandemic.

Authors:  Parya Saberi
Journal:  AIDS Behav       Date:  2020-08
  8 in total

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