Literature DB >> 24694932

Antiretroviral concentrations in small hair samples as a feasible marker of adherence in rural Kenya.

Matthew D Hickey1, Charles R Salmen, Robert A Tessler, Dan Omollo, Peter Bacchetti, Richard Magerenge, Brian Mattah, Marcus R Salmen, Daniel Zoughbie, Kathryn J Fiorella, Elvin Geng, Betty Njoroge, Chengshi Jin, Yong Huang, Elizabeth A Bukusi, Craig R Cohen, Monica Gandhi.   

Abstract

Antiretroviral hair levels objectively quantify drug exposure over time and predict virologic responses. We assessed the acceptability and feasibility of collecting small hair samples in a rural Kenyan cohort. Ninety-five percentage of participants (354/373) donated hair. Although median self-reported adherence was 100% (interquartile range, 96%-100%), a wide range of hair concentrations likely indicates overestimation of self-reported adherence and the advantages of a pharmacologic adherence measure. Higher nevirapine hair concentrations observed in women and older adults require further study to unravel behavioral versus pharmacokinetic contributors. In resource-limited settings, hair antiretroviral levels may serve as a low-cost quantitative biomarker of adherence.

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Year:  2014        PMID： 24694932      PMCID： PMC4146734          DOI： 10.1097/QAI.0000000000000154

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN： 1525-4135            Impact factor:   3.731


  39 in total

1.  Indinavir hair concentration in highly active antiretroviral therapy-treated patients: association with viral load and drug resistance.

Authors:  J Servais; G Peytavin; V Arendt; T Staub; F Schneider; R Hemmer; G Burtonboy; J C Schmit
Journal:  AIDS       Date:  2001-05-04       Impact factor: 4.177

2.  A comparison study of multiple measures of adherence to HIV protease inhibitors.

Authors:  H Liu; C E Golin; L G Miller; R D Hays; C K Beck; S Sanandaji; J Christian; T Maldonado; D Duran; A H Kaplan; N S Wenger
Journal:  Ann Intern Med       Date:  2001-05-15       Impact factor: 25.391

3.  Sex differences in adherence to highly active antiretroviral therapy: a meta-analysis.

Authors:  C Ortego; T B Huedo-Medina; P Santos; E Rodríguez; L Sevilla; M Warren; J Llorca
Journal:  AIDS Care       Date:  2012-04-25

4.  Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient Care Committee & Adherence Working Group of the Outcomes Committee of the Adult AIDS Clinical Trials Group (AACTG).

Authors:  M A Chesney; J R Ickovics; D B Chambers; A L Gifford; J Neidig; B Zwickl; A W Wu
Journal:  AIDS Care       Date:  2000-06

5.  Adherence to antiretroviral therapy in HIV-positive adolescents in Uganda assessed by multiple methods: a prospective cohort study.

Authors:  Matthew O Wiens; Stuart MacLeod; Victor Musiime; Mark Ssenyonga; Ruth Kizza; Sabrina Bakeera-Kitaka; Richard Odoi-Adome; Francis Ssali
Journal:  Paediatr Drugs       Date:  2012-10-01       Impact factor: 3.022

6.  Assessing the association between self-report items for HIV pill adherence and biological measures.

Authors:  Ashraf Kagee; Adriaan Nel
Journal:  AIDS Care       Date:  2012-06-07

7.  Effects of age on antiretroviral plasma drug concentration in HIV-infected subjects undergoing routine therapeutic drug monitoring.

Authors:  Alan Winston; Sophie Jose; Sara Gibbons; David Back; Wolfgang Stohr; Frank Post; Martin Fisher; Brian Gazzard; Mark Nelson; Richard Gilson; Chloe Orkin; Margaret Johnson; Adrian Palfreeman; David Chadwick; Clifford Leen; Achim Schwenk; Jane Anderson; Mark Gompels; David Dunn; Saye Khoo; Caroline Sabin
Journal:  J Antimicrob Chemother       Date:  2013-02-23       Impact factor: 5.790

8.  Differences between self-reported and electronically monitored adherence among patients receiving antiretroviral therapy in a resource-limited setting.

Authors:  Harsha Thirumurthy; Nalyn Siripong; Rachel C Vreeman; Cristian Pop-Eleches; James P Habyarimana; John E Sidle; Abraham M Siika; David R Bangsberg
Journal:  AIDS       Date:  2012-11-28       Impact factor: 4.177

9.  Hair and plasma data show that lopinavir, ritonavir, and efavirenz all transfer from mother to infant in utero, but only efavirenz transfers via breastfeeding.

Authors:  Monica Gandhi; Julia Mwesigwa; Francesca Aweeka; Albert Plenty; Edwin Charlebois; Theodore D Ruel; Yong Huang; Tamara Clark; Veronica Ades; Paul Natureeba; Flavia A Luwedde; Jane Achan; Moses R Kamya; Diane V Havlir; Deborah Cohan
Journal:  J Acquir Immune Defic Syndr       Date:  2013-08-15       Impact factor: 3.731

10.  Preexposure prophylaxis for HIV infection among African women.

Authors:  Lut Van Damme; Amy Corneli; Khatija Ahmed; Kawango Agot; Johan Lombaard; Saidi Kapiga; Mookho Malahleha; Fredrick Owino; Rachel Manongi; Jacob Onyango; Lucky Temu; Modie Constance Monedi; Paul Mak'Oketch; Mankalimeng Makanda; Ilse Reblin; Shumani Elsie Makatu; Lisa Saylor; Haddie Kiernan; Stella Kirkendale; Christina Wong; Robert Grant; Angela Kashuba; Kavita Nanda; Justin Mandala; Katrien Fransen; Jennifer Deese; Tania Crucitti; Timothy D Mastro; Douglas Taylor
Journal:  N Engl J Med       Date:  2012-07-11       Impact factor: 91.245
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  53 in total

1.  Analysis of Antiretrovirals in Single Hair Strands for Evaluation of Drug Adherence with Infrared-Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Imaging.

Authors:  Elias P Rosen; Corbin G Thompson; Mark T Bokhart; Heather M A Prince; Craig Sykes; David C Muddiman; Angela D M Kashuba
Journal:  Anal Chem       Date:  2015-12-30       Impact factor: 6.986

2.  Development and validation of an assay to analyze atazanavir in human hair via liquid chromatography/tandem mass spectrometry.

Authors:  Nhi Phung; Karen Kuncze; Hideaki Okochi; Alexander Louie; Leslie Z Benet; Igho Ofokotun; David W Haas; Judith S Currier; Tariro D Chawana; Anandi N Sheth; Peter Bacchetti; Monica Gandhi; Howard Horng
Journal:  Rapid Commun Mass Spectrom       Date:  2018-03-15       Impact factor: 2.419

3.  Behavioral intervention improves treatment outcomes among HIV-infected individuals who have delayed, declined, or discontinued antiretroviral therapy: a randomized controlled trial of a novel intervention.

Authors:  Marya Gwadz; Charles M Cleland; Elizabeth Applegate; Mindy Belkin; Monica Gandhi; Nadim Salomon; Angela Banfield; Noelle Leonard; Marion Riedel; Hannah Wolfe; Isaiah Pickens; Kelly Bolger; DeShannon Bowens; David Perlman; Donna Mildvan
Journal:  AIDS Behav       Date:  2015-10

4.  Simultaneous analysis of 11 medications for drug resistant TB in small hair samples to quantify adherence and exposure using a validated LC-MS/MS panel.

Authors:  Roy Gerona; Anita Wen; David Aguilar; Jamie Shum; Andrew Reckers; Peter Bacchetti; Monica Gandhi; John Metcalfe
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2019-07-23       Impact factor: 3.205

5.  Positive affect and medication adherence in chronic conditions: A systematic review.

Authors:  Sarah M Bassett; Stephanie A Schuette; Linda C O'Dwyer; Judith T Moskowitz
Journal:  Health Psychol       Date:  2019-08-01       Impact factor: 4.267

6.  Perinatal Food Insecurity and Postpartum Psychosocial Stress are Positively Associated Among Kenyan Women of Mixed HIV Status.

Authors:  Pamela M Murnane; Joshua D Miller; Emily L Tuthill; Shalean M Collins; Torsten B Neilands; Maricianah Onono; Craig R Cohen; Sheri D Weiser; Mark L Laudenslager; Sera L Young
Journal:  AIDS Behav       Date:  2020-06

Review 7.  Approaches to Objectively Measure Antiretroviral Medication Adherence and Drive Adherence Interventions.

Authors:  Matthew A Spinelli; Jessica E Haberer; Peter R Chai; Jose Castillo-Mancilla; Peter L Anderson; Monica Gandhi
Journal:  Curr HIV/AIDS Rep       Date:  2020-08       Impact factor: 5.071

8.  Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women.

Authors:  Pamela M Murnane; Peter Bacchetti; Judith S Currier; Sean Brummel; Hideaki Okochi; Nhi Phung; Alexander Louie; Karen Kuncze; Risa M Hoffman; Teacler Nematadzira; Dean K Soko; Maxensia Owor; Friday Saidi; Patricia M Flynn; Mary G Fowler; Monica Gandhi
Journal:  AIDS       Date:  2019-08-01       Impact factor: 4.177

9.  Assessment of HIV antiretroviral therapy adherence by measuring drug concentrations in hair among children in rural Uganda.

Authors:  Peter K Olds; Julius P Kiwanuka; Denis Nansera; Yong Huang; Peter Bacchetti; Chengshi Jin; Monica Gandhi; Jessica E Haberer
Journal:  AIDS Care       Date:  2014-12-06

10.  CYP2B6*6 and CYP2B6*18 Predict Long-Term Efavirenz Exposure Measured in Hair Samples in HIV-Positive South African Women.

Authors:  Carola R Röhrich; Britt I Drögemöller; Ogechi Ikediobi; Lize van der Merwe; Nelis Grobbelaar; Galen E B Wright; Nathaniel McGregor; Louise Warnich
Journal:  AIDS Res Hum Retroviruses       Date:  2016-01-29       Impact factor: 2.205
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