| Literature DB >> 31756377 |
Rong-Ting Duan1, Rui-Ning Yang1, Hong-Tao Li1, Lin-Huan Tang1, Tao Liu1, Ya-Bin Yang1, Hao Zhou2, Zhong-Tao Ding3.
Abstract
Peniterester (1), a new tricyclic sesquiterpene, together with 6 known compounds (2-7) were isolated from the secondary metabolites of an artificial mutant Penicillium sp. T2-M20 which was obtained from the parental strain Penicillium sp. T2-8 via UV irradiation as well as nitrosoguanidine (NTG) induction. Peniterester was only produced by the mutant T2-M20 on the basis of LC-MS analysis. Meanwhile, the results of in vitro bioactivities screening indicated that peniterester owned obvious antibacterial activities against Bacillus subtilis, Escherichia coli and Staphylococcus aureus with MICs of 8.0, 8.0 and 4.0 μg/mL, respectively.Entities:
Keywords: Antibacterial activity; Artificial mutation; Penicillium sp.; Secondary metabolites; Sesquiterpene
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Year: 2019 PMID： 31756377 DOI： 10.1016/j.fitote.2019.104422
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882